Category Archives: Schizophrenia

Autism – Shared Epigenetic Changes at or near 12 Months for 68% of ASD

Shared epigenetic changes underlie different types of autism  www.cell.com Individuals with both rare and common types of autism spectrum disorder share a similar set of epigenetic modifications in the brain, according to a study published November 17 in Cell. More … Continue reading

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Environmental Enrichment as a Treatment for Early Life Inflammation

Environmental enrichment rescues the effects of early life inflammation on markers of synaptic transmission and plasticity. http://www.ncbi.nlm.nih.gov/pubmed/27002704  Abstract Environmental enrichment (EE) has been successful at rescuing the brain from a variety of early-life psychogenic stressors. However, its ability to reverse … Continue reading

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Breakthrough – Autism, Immune Cells and Pruning

The Brain’s Gardeners: Immune Cells ‘Prune’ Connections Between Neurons https://www.urmc.rochester.edu A new study out today in the journal Nature Communications shows that cells normally associated with protecting the brain from infection and injury also play an important role in rewiring … Continue reading

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Glutamate and a range of Disorders

Glutamate transporter dysfunction and major mental illnesses http://www.ncbi.nlm.nih.gov/pubmed/26793898 Abstract Glutamate is the main excitatory neurotransmitter in the central nervous system and plays an important role in most aspects of normal brain function. In this review, we demonstrate that various kinds … Continue reading

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Prenatal Infection , Autism and Treatment Options

Long-term pathological consequences of prenatal infection: Beyond brain disorders. http://www.ncbi.nlm.nih.gov/pubmed/25924881 Abstract Immune-related prenatal adversities such as maternal infection have been widely acknowledged to contribute to an increased risk of neurodevelopmental brain disorders. In recent years, epidemiological and experimental evidence has … Continue reading

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Schizophrenia – The Dual Hit Model

Neurodevelopmental Animal Models Reveal the Convergent Role of Neurotransmitter Systems, Inflammation, and Oxidative Stress as Biomarkers of Schizophrenia: Implications for Novel Drug Development. http://www.ncbi.nlm.nih.gov/pubmed/25794269 Abstract Schizophrenia is a life altering disease with a complex etiology and pathophysiology, and although antipsychotics … Continue reading

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Vitamin D and Autism II

Vitamin D status in autism spectrum disorders and the efficacy of vitamin D supplementation in autistic children. http://www.ncbi.nlm.nih.gov/pubmed/25876214 Abstract Objectives Autism spectrum disorder (ASD) is a developmental disorder characterized by pervasive deficits in social interaction, impairment in verbal and non-verbal … Continue reading

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Nature Special – Innovations in the Microbiome

Innovations in the Microbiome ========================= **The Microbes Within David Grogan http://links.ealert.nature.com/ctt?kn=98&ms=NDgxMDM3OTcS1&r=MjA1NzQ2MzIyOAS2&b=2&j=NjIzMTMwNzQxS0&mt=1&rt=0 **Gut Microbiome: The Peacekeepers Moises Velasquez-Manoff http://links.ealert.nature.com/ctt?kn=81&ms=NDgxMDM3OTcS1&r=MjA1NzQ2MzIyOAS2&b=2&j=NjIzMTMwNzQxS0&mt=1&rt=0 **Why Microbiome Treatments Could Pay Off Soon Rob Knight http://links.ealert.nature.com/ctt?kn=90&ms=NDgxMDM3OTcS1&r=MjA1NzQ2MzIyOAS2&b=2&j=NjIzMTMwNzQxS0&mt=1&rt=0 **The Gene–Microbe Link Ruth E. Ley http://links.ealert.nature.com/ctt?kn=88&ms=NDgxMDM3OTcS1&r=MjA1NzQ2MzIyOAS2&b=2&j=NjIzMTMwNzQxS0&mt=1&rt=0 **Your Microbes at Work: Fiber … Continue reading

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Natural Rhythms and the Development of Mental Illness

Deconstructing mental illness through ultradian rhythms http://www.douglas.qc.ca/news/1326 Might living a structured life with regularly established meal times and early bedtimes lead to a better life and perhaps even prevent the onset of mental illness? That’s what’s suggested in a study … Continue reading

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Psychiatric Disorders and neuronal, immune and histone pathways

Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways http://www.nature.com Genome-wide association studies (GWAS) of psychiatric disorders have identified multiple genetic associations with such disorders, but better methods are needed to derive the underlying biological mechanisms that these … Continue reading

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