Monthly Archives: November 2014

Histamine and Brain Disorders – Implications for Autism.

Posted on November 29, 2014 by researchinitiative

Histaminergic system in brain disorders: lessons from the translational approach and future perspectives http://www.annals-general-psychiatry.com/content/13/1/34 Full Text at Link Histamine and its receptors were first described as part of immune and gastrointestinal systems, but their presence in the central nervous system … Continue reading →

Posted in Allergy, Asthma, Autism, Environment, Gut, Immune System, Inflammation, Neurology, Treatment | Leave a comment

Immune Insults in Autism – A New Subset ( ASD -Inflammatory Subtype)

Posted on November 27, 2014 by researchinitiative

Cytokine profiles by peripheral blood monocytes are associated with changes in behavioral symptoms following immune insults in a subset of ASD subjects: an inflammatory subtype? http://www.jneuroinflammation.com/content/11/1/187 Abstract Background Some children with autism spectrum disorders (ASD) are characterized by fluctuating behavioral … Continue reading →

Posted in Autism, Immune System, Inflammation, Physiology, Treatment, Virus | Leave a comment

Maternal Immune Activation – IL-6 and Disruption of Brain Development in Autism

Posted on November 27, 2014 by researchinitiative

Metabolic consequences of interleukin-6 challenge in developing neurons and astroglia http://www.jneuroinflammation.com/content/11/1/183 Abstract Background Maternal immune activation and subsequent interleukin-6 (IL-6) induction disrupt normal brain development and predispose the offspring to developing autism and schizophrenia. While several proteins have been identified … Continue reading →

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Neuroinflammation and Autism – Imbalance in GABAergic and glutamatergic synapses as a consequence of neuroinflammation.

Posted on November 27, 2014 by researchinitiative

GABAergic/glutamatergic imbalance relative to excessive neuroinflammation in autism spectrum disorders  http://www.jneuroinflammation.com/content/11/1/189 Background Autism spectrum disorder (ASD) is characterized by three core behavioral domains: social deficits, impaired communication, and repetitive behaviors. Glutamatergic/GABAergic imbalance has been found in various preclinical models of … Continue reading →

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The Gut – Beneficial Virus and Bacteria – Implications for Autism ?

Posted on November 20, 2014 by researchinitiative

Natural Gut Viruses Join Bacterial “Cousins” in Maintaining Health and Fighting Infections http://communications.med.nyu.edu Study in mice suggests “virome” as helpful as “microbiome” in people, too Microbiologists at NYU Langone Medical Center say they have what may be the first strong … Continue reading →

Posted in Autism, Bacteria, bowel disease, co-morbid, Environment, Gut, Immune System, Inflammation, influenza, Mice, Neurology, Toxins, Treatment | Leave a comment

The Blood Brain Barrier and Microglia

Posted on November 19, 2014 by researchinitiative

The impact of microglial activation on blood-brain barrier in brain diseases. http://www.ncbi.nlm.nih.gov/pubmed/25404894 The blood-brain barrier (BBB), constituted by an extensive network of endothelial cells (ECs) together with neurons and glial cells, including microglia, forms the neurovascular unit (NVU). The crosstalk … Continue reading →

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Gut Microbes and Neuroscience – The Paradigm Shift

Posted on November 15, 2014 by researchinitiative

Gut microbes and the brain: paradigm shift in neuroscience. http://www.ncbi.nlm.nih.gov/pubmed/25392516 Abstract The discovery of the size and complexity of the human microbiome has resulted in an ongoing reevaluation of many concepts of health and disease, including diseases affecting the CNS. … Continue reading →

Posted in Allergy, Asthma, Autism, Bacteria, bowel disease, co-morbid, Depression, diabetes, Environment, Epigenetics, Genetics, Gut, IBD, Immune System, Inflammation, Neurology, Parents, Physiology, Schizophrenia | Leave a comment

Schizophrenia and Bacteria – Toxoplasma gondii may account for as much as 21%

Posted on November 15, 2014 by researchinitiative

Estimating the population attributable fraction for schizophrenia when Toxoplasma gondii is assumed absent in human populations http://www.sciencedirect.com Highlights •There is evidence that Toxoplasma gondii may be a component cause of schizophrenia. We describe a new method for estimating the population … Continue reading →

Posted in Autism, Bacteria, co-morbid, Schizophrenia | Leave a comment

Depression as Infectious Disease

Posted on November 15, 2014 by researchinitiative

Could Depression Actually be a form of Infectious Disease? Paper by Stony Brook’s Turhan Canli in Biology of Mood & Anxiety Disorder points to evidence that suggests research should explore this possibility http://sb.cc.stonybrook.edu Stony Brook, NY, November 14, 2014 – … Continue reading →

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Black and Hispanic Children – Autism Identification – Underrepresented.

Posted on November 11, 2014 by researchinitiative

Study shows black, Hispanic children underrepresented in autism identification http://news.ku.edu LAWRENCE — The number of children diagnosed with autism has increased in recent years, but a new study co-authored by a University of Kansas professor shows that while the number of … Continue reading →

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