Monthly Archives: January 2014

Familial Transmission of ASD – Mothers with ADHD

Shared familial transmission of autism spectrum and attention-deficit/hyperactivity disorders. http://www.ncbi.nlm.nih.gov/pubmed/24444366 Abstract BACKGROUND: To determine whether familial transmission is shared between autism spectrum disorders and attention-deficit/hyperactivity disorder, we assessed the prevalence, rates of comorbidity, and familial transmission of both disorders in … Continue reading

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Intellectual Disability in Autism – Distinct Therapeutic Strategies

Long-Term Memory Deficits are Associated with Elevated Synaptic ERK1/2 Activation and Reversed by mGluR5 Antagonism in an Animal Model of Autism. http://www.ncbi.nlm.nih.gov/pubmed/24448645 Abstract A significant proportion of patients with autism exhibit some degree of intellectual disability. The BTBR T+ Itpr3tf/J … Continue reading

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White Matter Tracts and ASD – MIT New Findings

Differences in the right inferior longitudinal fasciculus but no general disruption of white matter tracts in children with autism spectrum disorder. http://www.ncbi.nlm.nih.gov/pubmed/24449864 Abstract One of the most widely cited features of the neural phenotype of autism is reduced “integrity” of … Continue reading

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Household Pesticides and Autism

Autism spectrum disorder, flea and tick medication, and adjustments for exposure misclassification: the CHARGE (CHildhood Autism Risks from Genetics and Environment) case-control study. http://www.ncbi.nlm.nih.gov/pubmed/24456651 BACKGROUND: The environmental contribution to autism spectrum disorders (ASD) is largely unknown, but household pesticides are … Continue reading

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Lipopolysaccharide, Propionic Acid and ASD

Pre- and neonatal exposure to lipopolysaccharide or the enteric metabolite, propionic Acid, alters development and behavior in adolescent rats in a sexually dimorphic manner. http://www.ncbi.nlm.nih.gov/pubmed/24466331 Abstract Alterations in the composition of the gut microbiome and/or immune system function may have … Continue reading

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Diet, Microbes and Inflammatory Bowel Disease

Diet rapidly and reproducibly alters the human gut microbiome http://www.nature.com Long-term dietary intake influences the structure and activity of the trillions of microorganisms residing in the human gut1, 2, 3, 4, 5, but it remains unclear how rapidly and reproducibly … Continue reading

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Glial Markers for Autism research

Altered glial marker expression in autistic post-mortem prefrontal cortex and cerebellum. http://www.ncbi.nlm.nih.gov/pubmed/24410870 The cellular mechanism(s) underlying autism spectrum disorders (ASDs) are not completely understood, but ASDs are thought to ultimately result from disrupted synaptogenesis. However, studies have also shown that … Continue reading

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Pre- and Perinatal Risk Factors for Autism Spectrum

Pre- and Perinatal Risk Factors for Autism Spectrum Disorder in a New Jersey Cohort. http://www.ncbi.nlm.nih.gov/pubmed/24413357 Abstract This study evaluated the prevalence of pre- and perinatal risk factors in a cohort of children with autism spectrum disorders compared with the New … Continue reading

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New Approaches needed for Autism Research.

Autism: metabolism, mitochondria, and the microbiome. http://www.ncbi.nlm.nih.gov/pubmed/24416709 New approaches are needed to examine the diverse symptoms and comorbidities of the growing family of neurodevelopmental disorders known as autism spectrum disorder (ASD). ASD originally was thought to be a static, inheritable … Continue reading

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Brain Imaging Abnormalities in 2-3 Years Old Toddlers.

Autism Spectrum Disorder as Early Neurodevelopmental Disorder: Evidence from the Brain Imaging Abnormalities in 2-3¬†Years Old Toddlers. http://www.ncbi.nlm.nih.gov/pubmed/24419870 Abstract Autism spectrum disorder (ASD) is a complex neurodevelopmental condition that occurs within the first 3¬†years of life, which is marked by … Continue reading

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