White Matter Tracts and ASD – MIT New Findings

Differences in the right inferior longitudinal fasciculus but no general disruption of white matter tracts in children with autism spectrum disorder.

http://www.ncbi.nlm.nih.gov/pubmed/24449864

Abstract

One of the most widely cited features of the neural phenotype of autism is reduced “integrity” of long-range white matter tracts, a claim based primarily on diffusion imaging studies.

However, many prior studies have small sample sizes and/or fail to address differences in data quality between those with autism spectrum disorder (ASD) and typical participants, and there is little consensus on which tracts are affected.

To overcome these problems, we scanned a large sample of children with autism (n = 52) and typically developing children (n = 73). Data quality was variable, and worse in the ASD group, with some scans unusable because of head motion artifacts.

When we follow standard data analysis practices (i.e., without matching head motion between groups), we replicate the finding of lower fractional anisotropy (FA) in multiple white matter tracts.

However, when we carefully match data quality between groups, all these effects disappear except in one tract, the right inferior longitudinal fasciculus (ILF).

Additional analyses showed the expected developmental increases in the FA of fiber tracts within ASD and typical groups individually, demonstrating that we had sufficient statistical power to detect known group differences.

Our data challenge the widely claimed general disruption of white matter tracts in autism, instead implicating only one tract, the right ILF, in the ASD phenotype.

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Further Readings of Interest

http://en.wikipedia.org/wiki/Inferior_longitudinal_fasciculus

Anatomy and functional role of the inferior longitudinal fasciculus: a search that has just begun

http://onlinelibrary.wiley.com/doi/10.1111/j.1469-8749.2011.04122.x/full

“A recent review by Chanraud et al.7 provides a comprehensive review of diseases with ILF involvement and other major white matter fiber bundles. As discussed by Chanraud et al., the ILF has functionally been correlated with thought disorders, visual emotion, cognitive impairments, and other symptoms.”

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This entry was posted in Autism, Neurology, Schizophrenia. Bookmark the permalink.

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