Monthly Archives: December 2012

Valproic Acid and Schizophrenia in Mice

Prophylactic Valproic Acid Treatment Prevents Schizophrenia-Related Behaviour in Disc1-L100P Mutant Mice. http://www.ncbi.nlm.nih.gov/pubmed/23272119 Samuel Lunenfeld Research Institute at Mount Sinai Hospital, Toronto, Ontario, Canada. Abstract BACKGROUND: Schizophrenia is a neurodevelopmental disorder with onset early in adulthood. Disrupted-In-Schizophrenia-1 (DISC1) is a susceptibility … Continue reading

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An Inflexible Mouse – BTBR and BDNF – and the Gut.

Reduced social interaction, behavioural flexibility and BDNF signalling in the BTBR T+tf/J strain, a mouse model of autism. http://www.ncbi.nlm.nih.gov/pubmed/23270976 Department of Cell Biology and Neuroscience, Istituto Superiore di Sanità, Viale Regina Elena, 299 I-00161 Rome, Italy. Abstract Autism is a … Continue reading

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Converging Enivronment and Genetics – Key Signalling Pathways

Neuronal connectivity as a convergent target of gene-environment interactions that confer risk for Autism Spectrum Disorders. http://www.ncbi.nlm.nih.gov/pubmed/23269408 Department of Molecular Biosciences, University of California at Davis School of Veterinary Medicine Abstract Evidence implicates environmental factors in the pathogenesis of Autism … Continue reading

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The Immune System and the Neonatal Period in Autism

Neonatal chemokine levels and risk of autism spectrum disorders: Findings from a Danish historic birth cohort follow-up study. http://www.ncbi.nlm.nih.gov/pubmed/23267761 Section for Epidemiology, Aarhus University HEALTH, Bartholins Allé 2, Aarhus C 8000, Denmark; Department of Clinical Biochemistry and Immunology Statens Serum … Continue reading

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Glucose Metabolism, Cytotoxic T lymphocytes and mTOR

Cellular Metabolism Arms T Cells to Battle Viruses and Tumors http://www.sciencedaily.com/releases/2012/12/121224113420.htm Dec. 24, 2012 — New research demonstrates that the cellular metabolism of certain immune cells is closely linked to their function, which includes protecting against viral infections and the … Continue reading

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C-Reactive Protein, Inflammation and Depression

Elevated Levels of C-Reactive Protein Appear Associated With Psychological Distress, Depression http://www.sciencedaily.com/releases/2012/12/121226081050.htm Dec. 24, 2012 — Elevated levels of C-reactive protein, a marker of inflammatory disease, appear to be associated with increased risk of psychological distress and depression in the … Continue reading

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uPAR, Epilepsy and Autism

Urokinase-Type Plasminogen Activator Receptor Modulates Epileptogenesis in Mouse Model of Temporal Lobe Epilepsy. http://www.ncbi.nlm.nih.gov/pubmed/23263886 Department of Neurobiology, A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland Abstract Mutation in Plaur gene encoding urokinase-type plasminogen activator receptor (uPAR) results … Continue reading

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Co-morbidity Autism and ADHD

Co-morbidity and factor analysis on attention deficit hyperactivity disorder and autism spectrum disorder DSM-IV-derived items. http://www.ncbi.nlm.nih.gov/pubmed/23267399 Research Center for Psychiatry and Behavioral Sciences, Shiraz University of Medical Sciences, Shiraz, Iran ; Department of Psychiatry, School of Medicine, Shiraz University of … Continue reading

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Gene Expression – Bipolar Disorder – Immune System

Up-Regulation of NOTCH4 Gene Expression in Bipolar Disorder. http://www.ncbi.nlm.nih.gov/pubmed/23212060 Abstract OBJECTIVE Immunopathogenic mechanisms have been implicated in schizophrenia and bipolar disorder, and genome-wide association studies (GWAS) point to the major histocompatibility complex, a region that contains many immune-related genes. One … Continue reading

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Gene Expression in Schizophrenia – Immune Pathways

Gene expression analysis reveals schizophrenia-associated dysregulation of immune pathways in peripheral blood mononuclear cells. http://www.ncbi.nlm.nih.gov/pubmed/23218666 Schizophrenia Research Institute, Sydney, NSW, Australia; Abstract Peripheral blood mononuclear cells (PBMCs) represent an accessible tissue source for gene expression profiling in schizophrenia that could provide … Continue reading

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