Glutamate transporter dysfunction and major mental illnesses
http://www.ncbi.nlm.nih.gov/pubmed/26793898
Abstract
Glutamate is the main excitatory neurotransmitter in the central nervous system and plays an important role in most aspects of normal brain function.
In this review, we demonstrate that various kinds of GLT1 and/or GLAST knockout mice replicate many aspects of the behavioral abnormalities seen in major mental illnesses including schizophrenia, depression, obsessive -compulsive disorders, autism, epilepsy and addiction.
Further Readings of Interest
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