Allergic Diseases and Epilepsy – Severe Eczema 3.89 (OR)

Allergic disease is associated with epilepsy in childhood: a US population-based study.

http://www.ncbi.nlm.nih.gov/pubmed/24251558

Previous studies using animal models suggest an association between allergic disease and epilepsy. We sought to determine whether allergic disease is associated with epilepsy in children.

METHODS:

We used the 2007-2008 National Survey of Children’s Health, a US population-based study of 91 642 children aged 0-17 years to determine the association between the prevalence of epilepsy and allergic disease, including asthma, atopic dermatitis (AD)/eczema, hay fever, and food allergies. Multivariate logistic regression models were constructed that controlled for confounding variables.

RESULTS:

The US lifetime prevalence of childhood epilepsy was 1.03% and was significantly associated with older age, male sex, lower household income, family structure and history of brain injury or concussion.

Children with ≥1 allergic disease had more epilepsy in their lifetime than nonallergic children (logistic regression, adjusted odds ratio [95% confidence interval] = 1.79 [1.37-2.33]).

Lifetime prevalence (2.30 [1.50-3.52]) and

one-year prevalence of asthma (2.00 [1.41-2.84]),

AD/eczema (1.73 [1.17-2.56]),

hay fever (1.93 [1.41-2.65]) and

food allergies (2.69 [1.38-4.01])

were associated with increased odds of ever being diagnosed with epilepsy. Similar results were found for current history of epilepsy.

Severe AD/eczema (3.89 [1.34-11.32]) and hay fever (2.46 [1.11-5.41]) were associated with even higher odds of epilepsy compared with mild/moderate disease.

As the number of allergic diseases increased, so did the odds of lifetime history and current history of epilepsy.

CONCLUSIONS:

The US prevalence of epilepsy is associated with allergic diseases in children. Further studies are needed to determine whether allergic inflammation contributes toward epileptogenesis.

© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

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Further Readings of Interest

Eczema and Autism

https://asdresearchinitiative.wordpress.com/?s=eczema+autism

Epilepsy and Autism

https://asdresearchinitiative.wordpress.com/?s=epilepsy+autism

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This entry was posted in Allergy, Asthma, Autism, co-morbid, Depression, Environment, Gut, Immune System, Inflammation, Neurology, Physiology, Treatment. Bookmark the permalink.

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