Monthly Archives: February 2015

Genetic Overlap – Fever Associated Epilepsy and Autism.

Investigating the genetic basis of fever-associated syndromic epilepsies using copy number variation analysis. Abstract Fever-associated syndromic epilepsies ranging from febrile seizures plus (FS+) to Dravet syndrome have a significant genetic component. However, apart from SCN1A mutations in >80% of … Continue reading

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Peanut Allergy – Autism and HLA

Genome-wide association study identifies peanut allergy-specific loci and evidence of epigenetic mediation in US children. Abstract Food allergy (FA) affects 2%-10% of US children and is a growing clinical and public health problem. Here we conduct the first genome-wide … Continue reading

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Prenatal Stress and the Development of Socioemotional Behavior

Prenatal stress alters the development of socioemotional behavior and amygdala neuron excitability in rats. Abstract Prenatal stress (PS) is a risk factor for neurodevelopmental disorders with diverse ages of onset and socioemotional symptoms. Some PS-linked disorders involve characteristic social … Continue reading

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Nature Special – Innovations in the Microbiome

Innovations in the Microbiome ========================= **The Microbes Within David Grogan **Gut Microbiome: The Peacekeepers Moises Velasquez-Manoff **Why Microbiome Treatments Could Pay Off Soon Rob Knight **The Gene–Microbe Link Ruth E. Ley **Your Microbes at Work: Fiber … Continue reading

Posted in Allergy, Asthma, Autism, Bacteria, bowel disease, co-morbid, Depression, diabetes, Environment, Epidemiology, Epigenetics, epilepsy, General, Genetics, Gut, IBD, Immune System, Inflammation, influenza, Mice, Muscular Dystrophy, Neurology, Physiology, Schizophrenia, Toxins, Treatment, Virus | Leave a comment

New Thinking – Antibiotics and Harmful Bacteria

Antibiotics give rise to new communities of harmful bacteria Researchers identify unexpected activity of antibiotics, potentially reshaping our understanding of why antibiotics evolved and pointing to broad health implications (Chapel Hill, N.C. – Feb. 23, 2015) – Most people … Continue reading

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Natural Rhythms and the Development of Mental Illness

Deconstructing mental illness through ultradian rhythms Might living a structured life with regularly established meal times and early bedtimes lead to a better life and perhaps even prevent the onset of mental illness? That’s what’s suggested in a study … Continue reading

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Allergy, Autoimmune Diseases and Autism – Kaiser Permanente Study

Immune Mediated Conditions in Autism Spectrum Disorders. Abstract We conducted a case-control study among members of Kaiser Permanente Northern California (KPNC) born between 1980 and 2003 to determine the prevalence of immune-mediated conditions in individuals with autism, investigate whether … Continue reading

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Maternal Immune Activation and Hyperactive Immune Response

Maternal Lipopolysaccharide Exposure Promotes Immunological Functional Changes in Adult Offspring CD4+ T Cells. Abstract PROBLEM: Maternal immune activation (MIA) is a risk factor for autism and schizophrenia. However, how MIA affects offspring immune function remains unknown. METHOD OF STUDY: … Continue reading

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Early Life Seizures and Autism – Retrospective

Early-life seizures result in deficits in social behavior and learning. Abstract Children with epilepsy show a high co-morbidity with psychiatric disorders and autism. One of the critical determinants of a child’s behavioral outcome with autism and cognitive dysfunction is … Continue reading

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Single Early Life Seizure and Autism Outcome

Behavioral changes following a single episode of early-life seizures support the latent development of an autistic phenotype. Abstract We probed the developmental and behavioral consequences of a single episode of kainic acid-induced early-life seizures (KA-ELS) in the rat on … Continue reading

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