Single Early Life Seizure and Autism Outcome

Behavioral changes following a single episode of early-life seizures support the latent development of an autistic phenotype.


We probed the developmental and behavioral consequences of a single episode of kainic acid-induced early-life seizures (KA-ELS) in the rat on postnatal day 7.

Correlates of developmental trajectory were not altered, demonstrating that long-term consequences following KA-ELS are not initiated by secondary causes, such as malnourishment or alterations in maternal care.

We report reduced marble burying in adult rats, suggestive of restricted interests, a trait common to experimental and clinical autism.

We did not detect increased repetitive grooming during habituated cage behavior.

However, we did detect reduced grooming in adult KA-ELS rats in the presence of an unfamiliar rat, supporting altered social anxiety following KA-ELS.

Reanalysis of a social approach task further indicated abnormal social interactions.

Taken together with previous physiological and behavioral data, these data support the hypothesis that KA-ELS lead to a latent autistic phenotype in adult rats not attributable to other early alterations in development.

Copyright © 2015 Elsevier Inc. All rights reserved.


Further Readings of Interest


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