Peanut Allergy – Autism and HLA

Genome-wide association study identifies peanut allergy-specific loci and evidence of epigenetic mediation in US children.

http://www.ncbi.nlm.nih.gov/pubmed/25710614

Abstract

Food allergy (FA) affects 2%-10% of US children and is a growing clinical and public health problem.

Here we conduct the first genome-wide association study of well-defined FA, including specific subtypes (peanut, milk and egg) in 2,759 US participants (1,315 children and 1,444 parents) from the Chicago Food Allergy Study, and identify peanut allergy (PA)-specific loci in the HLA-DR and -DQ gene region at 6p21.32, tagged by rs7192 (P=5.5 × 10(-8)) and rs9275596 (P=6.8 × 10(-10)), in 2,197 participants of European ancestry.

We replicate these associations in an independent sample of European ancestry. These associations are further supported by meta-analyses across the discovery and replication samples. Both single-nucleotide polymorphisms (SNPs) are associated with differential DNA methylation levels at multiple CpG sites (P<5 × 10(-8)), and differential DNA methylation of the HLA-DQB1 and HLA-DRB1 genes partially mediate the identified SNP-PA associations.

This study suggests that the HLA-DR and -DQ gene region probably poses significant genetic risk for PA.

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Further Readings of Interest

HLA / Autism

http://www.ncbi.nlm.nih.gov/pubmed/?term=HLA+Autism

https://asdresearchinitiative.wordpress.com/?s=HLA

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