Monthly Archives: September 2013

FOXO3 Pathway – Impact on Crohn’s , Rheumatoid Arthritis and Malaria

Posted on September 28, 2013 by researchinitiative

Human SNP Links Differential Outcomes in Inflammatory and Infectious Disease to a FOXO3-Regulated Pathway http://www.cell.com/abstract/S0092-8674%2813%2901028-3# Graphical Abstract – Audio Interview at Link mTor Signalling – Graphic available as PDF file here Highlights Reanalysis of GWAS data identifies a SNP associated … Continue reading →

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Folate Deficiency – 5 Generations – Epigentic Inheritance – Implications for Autism

Posted on September 28, 2013 by researchinitiative

Mutation in Folate Metabolism Causes Epigenetic Instability and Transgenerational Effects on Development http://www.cell.com/abstract/S0092-8674%2813%2901093-3 Graphical and Video Presentation at link – A must. Highlights Mutation in the Mtrr gene causes abnormal folate metabolism in mice Mtrr genotype of maternal grandparent affects … Continue reading →

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Genetic Map – Complex Diseases – 120 million patient records – Autism – Fragile X

Posted on September 27, 2013 by researchinitiative

A genetic map for complex diseases http://www.uchospitals.edu/news/2013/20130926-genetic-map.html September 26, 2013 Although heavily studied, the specific genetic causes of “complex diseases,” a category of disorders which includes autism, diabetes and heart disease, are largely unknown due to byzantine genetic and environmental … Continue reading →

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Maternal Viral Infection and Autism – Disruption of Neural Development

Posted on September 27, 2013 by researchinitiative

UC Davis researchers find how viral infection disrupts neural development in offspring, increasing risk of autism http://www.ucdmc.ucdavis.edu/publish/news/newsroom/8208 (SACRAMENTO, Calif.) — Activating a mother’s immune system during her pregnancy disrupts the development of neural cells in the brain of her offspring … Continue reading →

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Trends in Allergy – Eastern Europe – Georgia

Posted on September 27, 2013 by researchinitiative

Trends in the prevalence of childhood asthma and allergy in Western part of Georgia. http://www.ncbi.nlm.nih.gov/pubmed/24013149 Center for Allergy and Immunology Research, Tbilisi, Georgia. Abstract Internatinal time trend analyses, using the ISAAC (Phase Three) protocol, have yielded variable results and observed … Continue reading →

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Saliva – Dysbiosis – Inflammatory Bowel Disease

Posted on September 27, 2013 by researchinitiative

Dysbiosis of Salivary Microbiota in Inflammatory Bowel Disease and Its Association With Oral Immunological Biomarkers. http://www.ncbi.nlm.nih.gov/pubmed/24013298 Abstract Analysis of microbiota in various biological and environmental samples under a variety of conditions has recently become more practical due to remarkable advances … Continue reading →

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Immune-Endocrine Axis in Gut in Relation to Inflammation – IL13 – Serotonin

Posted on September 27, 2013 by researchinitiative

Interleukin 13 and serotonin: linking the immune and endocrine systems in murine models of intestinal inflammation. http://www.ncbi.nlm.nih.gov/pubmed/24015275 Abstract OBJECTIVE: Infiltration of activated immune cells and increased cytokine production define the immunophenotype of gastrointestinal (GI) inflammation. In addition, intestinal inflammation is … Continue reading →

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Gut Permeability – Sealing the Broken Barrier in Inflammatory Bowel Disease

Posted on September 27, 2013 by researchinitiative

Sealing The Broken Barrier in IBD: Intestinal Permeability, Epithelial Cells and Junctions. http://www.ncbi.nlm.nih.gov/pubmed/24060148 Abstract Inflammatory bowel diseases (IBD) are considered barrier diseases. After misleading initial results, the pathogenic importance of a disturbed mucosa is now widely accepted, largely because a … Continue reading →

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Pediatric Inflammatory Bowel Disease and Clostridium Perfringens

Posted on September 27, 2013 by researchinitiative

Enterotoxigenic Clostridium perfringens infection and pediatric patients with inflammatory bowel disease. http://www.ncbi.nlm.nih.gov/pubmed/24060617 Abstract BACKGROUND AND AIMS: Clostridium difficile is the major cause of antibiotic-associated diarrhea and is the most well known bacterial pathogen associated with inflammatory bowel disease (IBD). Enterotoxigenic … Continue reading →

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Elevated Plasma C-Reactive Protein and Schizophrenia – Inflammation

Posted on September 27, 2013 by researchinitiative

Elevated C-Reactive Protein Associated With Late- and Very-Late-Onset Schizophrenia in the General Population: A Prospective Study. http://www.ncbi.nlm.nih.gov/pubmed/23996346 Abstract Background: Individuals with autoimmune diseases and severe infections have persistent or acutely elevated inflammatory biomarkers and increased risk of schizophrenia. We tested … Continue reading →

Posted in Autism, co-morbid, Depression, Immune System, Inflammation, Neurology, Physiology, Schizophrenia, Treatment | Leave a comment