Prenatal Infection , Autism and Treatment Options

Long-term pathological consequences of prenatal infection: Beyond brain disorders.


Immune-related prenatal adversities such as maternal infection have been widely acknowledged to contribute to an increased risk of neurodevelopmental brain disorders.

In recent years, epidemiological and experimental evidence has accumulated to suggest that prenatal exposure to immune challenges can also negatively affect various physiological and metabolic functions beyond those typically associated with primary defects in CNS development.

These peripheral changes include excessive accumulation of adipose tissue and increased body weight, impaired glycemic regulation and insulin resistance, altered myeloid lineage development, increased gut permeability, hyperpurinergia, and changes in microbiota composition.

Experimental work in animal models further suggests that at least some of these peripheral abnormalities can directly contribute to CNS dysfunctions, so that normalization of peripheral pathologies can lead to an amelioration of behavioral deficits.

Hence, seemingly unrelated central and peripheral effects of prenatal infection could in fact represent interrelated pathological entities that emerge in response to a common developmental stressor. Targeting peripheral abnormalities may thus represent a valuable strategy to improve the wide spectrum of behavioral abnormalities that can emerge in subjects with prenatal infectious histories.

Copyright © 2015, American Journal of Physiology – Regulatory, Integrative and Comparative Physiology.


Further Readings of Interest

This entry was posted in Autism, co-morbid, Immune System, influenza, Neurology, Physiology, Schizophrenia, Virus. Bookmark the permalink.

Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s