Maternal autism-associated IgG antibodies delay development and produce anxiety in a mouse gestational transfer model.
Division of Rheumatology/Allergy and Clinical Immunology, University of California, Davis
The M.I.N.D. Institute, University of California, Davis
NIEHS Center for Children’s Environmental Health, University of California, Davis
A murine passive transfer model system was employed to ascertain the effects of gestational exposure to a single, intravenous dose of purified, brain-reactive IgG antibodies from individual mothers of children with autism (MAU) or mothers with typically developing children (MTD).
Growth and behavioral outcomes in offspring were measured from postnatal days 8 to 65 in each group. Comparisons revealed alterations in early growth trajectories, significantly impaired motor and sensory development, and increased anxiety.
This report demonstrates for the first time the effects of a single, low dose gestational exposure of IgG derived from individual MAU on their offspring’s physical and social development.