Mums , Mice and Autism – Maternal antibodies

Maternal autism-associated IgG antibodies delay development and produce anxiety in a mouse gestational transfer model.

http://www.ncbi.nlm.nih.gov/pubmed/22951357

Division of Rheumatology/Allergy and Clinical Immunology, University of California, Davis

The M.I.N.D. Institute, University of California, Davis

NIEHS Center for Children’s Environmental Health, University of California, Davis

Abstract

A murine passive transfer model system was employed to ascertain the effects of gestational exposure to a single, intravenous dose of purified, brain-reactive IgG antibodies from individual mothers of children with autism (MAU) or mothers with typically developing children (MTD).

Growth and behavioral outcomes in offspring were measured from postnatal days 8 to 65 in each group. Comparisons revealed alterations in early growth trajectories, significantly impaired motor and sensory development, and increased anxiety.

This report demonstrates for the first time the effects of a single, low dose gestational exposure of IgG derived from individual MAU on their offspring’s physical and social development.

Advertisements
This entry was posted in Autism, co-morbid, Immune System, Inflammation, Mice, Neurology, Physiology, Treatment and tagged , , , , , , , , , , . Bookmark the permalink.

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s