Daily Archives: August 21, 2014

Muscular Dystrophy and Autism – New Research focus on Females

Diagnostic and clinical characteristics of early-manifesting females with Duchenne or Becker muscular dystrophy. http://www.ncbi.nlm.nih.gov/pubmed/25125379 Abstract Manifestations of Duchenne and Becker muscular dystrophy (DBMD) are present in up to 40% of heterozygous females, but there are few reports of females who … Continue reading

Posted in Autism, co-morbid, Inflammation, Muscular Dystrophy, Neurology | Leave a comment

Vagus Nerve and Autism, Epilepsy, Depression and Schizophrenia

Vagal nerve stimulation blocks interleukin 6-dependent synaptic hyperexcitability induced by lipopolysaccharide-induced acute stress in the rodent prefrontal cortex. http://www.ncbi.nlm.nih.gov/pubmed/25128387 Abstract The ratio between synaptic inhibition and excitation (sI/E) is a critical factor in the pathophysiology of neuropsychiatric disease. We recently … Continue reading

Posted in Autism, co-morbid, Depression, Environment, Schizophrenia, Treatment | Leave a comment

The dynamic interplay between environmental and genetic factors – A Review

Epigenetic mechanisms in autism spectrum disorder. http://www.ncbi.nlm.nih.gov/pubmed/25131546 Abstract Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by impaired social interactions, language deficits, as well as restrictive or repetitive behaviors. ASD is clinically heterogeneous with a complex etiopathogenesis which may … Continue reading

Posted in Environment, Epigenetics, Genetics, Neurology, Physiology, Treatment | Leave a comment

Gene x Environment – A Review

Gene × Environment interactions in autism spectrum disorders: role of epigenetic mechanisms. http://journal.frontiersin.org/Journal/10.3389/fpsyt.2014.00053/full Full Paper at Link Abstract Several studies support currently the hypothesis that autism etiology is based on a polygenic and epistatic model. However, despite advances in epidemiological, molecular and … Continue reading

Posted in Autism, co-morbid, Environment, Genetics | Leave a comment

Alcohol Use Disorder and Risk for Autism – Increased Risk

Autism and attention-deficit/hyperactivity disorder among individuals with a family history of alcohol use disorders. http://www.ncbi.nlm.nih.gov/pubmed/25139954 Abstract Recent studies suggest de novo mutations may involve the pathogenesis of autism and attention-deficit/hyperactivity disorder (ADHD). Based on the evidence that excessive alcohol consumption … Continue reading

Posted in Autism, co-morbid, Environment, Genetics, Neurology, Physiology, Treatment | Leave a comment