Gut Microbiota, Clostridium and Liver Disease

Gut microbiota may play a role in the development of alcoholic liver disease

http://virtualpressoffice.easl.eu/gut-microbiota-may-play-a-role-in-the-development-of-alcoholic-liver/

London, UK, Saturday 12 April 2014:

Exciting new data presented today at the International Liver Congress™2014 shows that the gut microbiota has a potential role in the development of alcoholic liver disease (ALD).1Though an early stage animal model, the French study highlights the possibility of preventing ALD with faecal microbiota transplantation – the engrafting of new microbiota, usually through administering human faecal material from a healthy donor into the colon of a recipient.2

In the study, two groups of germ-free mice received gut microbiota transplants from human representatives; one set from a patient with severe alcoholic hepatitis, the other from a patient with a history of alcohol abuse but without alcoholic hepatitis. The two sets of germ-free mice were then fed a liquid alcoholic diet.

The group that received microbiota from the patient with severe alcoholic hepatitis developed a more severe liver injury and a higher disruption of the intestinal mucosa in direct comparison to the group that received microbiota from the patient without severe alcoholic hepatitis. The study also identified two Clostridium bacteria that were able to produce ethanol in vitro and that were systematically associated with intestinal microbiota associated liver injury.

EASL Scientific Committee Member Prof. Frank Lammert commented: “Among heavy drinkers, the severity of alcoholic liver disease does not strictly correlate with the amount of alcohol intake, meaning that other factors must be influencing its development.”

“These findings provide first evidence for a causal role of gut microbiota in alcohol-induced inflammation, and open up new avenues for the treatment of alcoholic liver disease with potentially better patient outcomes.” At present, intestinal microbiota is considered to constitute a “microbial organ”: one that has pivotal roles in the body’s metabolism as well as immune function. Therefore transplantation aims to restore gut functionality and re-establish the homoestasis of intestinal flora.

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Further Readings of Interest

https://asdresearchinitiative.wordpress.com/?s=clostridium

Investigation of the relation between anaerobic bacteria genus clostridium and late-onset autism etiology in children.

http://www.ncbi.nlm.nih.gov/pubmed/24063620

Enterotoxigenic Clostridium perfringens infection and pediatric patients with inflammatory bowel disease.

http://www.ncbi.nlm.nih.gov/pubmed/24060617

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This entry was posted in Autism, co-morbid, Environment, Gut, Immune System, Inflammation, Mice, Treatment. Bookmark the permalink.

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