Tag Archives: genetics

Autism – Environment for Boys , Genetics for Girls

Recurrence rates provide evidence for sex-differential, familial genetic liability for autism spectrum disorders in multiplex families and twins. http://www.ncbi.nlm.nih.gov/pubmed/25973164 BACKGROUND: Autism spectrum disorders (ASDs) are more prevalent in males, suggesting a multiple threshold liability model in which females are, on … Continue reading

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Diabetes Type 1 , Bacteria and Autism

Gut microbiota in children with type 1 diabetes differs from that in healthy children: a case-control study http://www.biomedcentral.com/1741-7015/11/46/abstract Background A recent study using a rat model found significant differences at the time of diabetes onset in the bacterial communities responsible … Continue reading

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Inflammatory Cytokines and Autism : A Relationship

Association of IL-12p70 and IL-6:IL-10 ratio with autism-related behaviors in 22q11.2 deletion syndrome: a preliminary report. http://www.ncbi.nlm.nih.gov/pubmed/23353117 Department of Psychiatry and Behavioral Sciences, Emory University, USA. Abstract 22q11.2 deletion syndrome (22q11DS) is a genetic disorder that conveys a significant risk … Continue reading

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mtDNA and Autism

Evidence of reactive oxygen species-mediated damage to mitochondrial DNA in children with typical autism. http://www.ncbi.nlm.nih.gov/pubmed/23347615 ABSTRACT: BACKGROUND: The mitochondrial genome (mtDNA) is particularly susceptible to damage mediated by reactive oxygen species (ROS). Although elevated ROS production and elevated biomarkers of … Continue reading

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Paternal Age : No Influence on CNV

Increased paternal age and the influence on burden of genomic copy number variation in the general population. http://www.ncbi.nlm.nih.gov/pubmed/23315237 Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht The Netherlands Abstract Genomic copy number variations (CNVs) and increased … Continue reading

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An Enriching Environment : Positive Effects on Autism ?

The effects of enriched environment on BDNF expression in the mouse cerebellum depending on the length of exposure. http://www.ncbi.nlm.nih.gov/pubmed/23295397 Área de Psicobiología, Universidad Jaume I, Castellon de la Plana, España. Abstract Environmental enrichment (EE) has been proposed as a factor … Continue reading

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Interesting Results from Organophospahtes and Autism in Mice

Decreased Reelin Expression and Organophosphate Pesticide Exposure Alters Mouse Behavior and Brain Morphology. http://www.ncbi.nlm.nih.gov/pubmed/23298182 Genetic and environmental factors are both likely to contribute to neurodevelopmental disorders, including autism spectrum disorders. In this study, we examined the combinatorial effect of two … Continue reading

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Obesity, Mothers and Vitamin D

Vitamin D levels in umbilical cord blood found to be lower if mother is obese http://www.northwestern.edu/newscenter/stories/2013/01/obese-moms-risk-having-babies-with-low-vitamin-d_mobile.html By Erin White CHICAGO — Women who are obese at the start of their pregnancy may be passing on insufficient levels of vitamin D … Continue reading

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Toxins , Genetic Susceptibility and Autism

Toxicity of the Flame-retardant BDE-49 on Brain Mitochondria and Neurons Enhanced by a PTEN-deficient Background. http://www.ncbi.nlm.nih.gov/pubmed/23288049 Department of Molecular Biosciences, School of Veterinary Medicine. Abstract Polybrominated diphenyl ethers (PBDEs) represent an important group of flame-retardants extensively used, which tonnage in … Continue reading

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Risk Gene for Alzheimer’s at Birth – Autism Implications.

Risk Genes for Alzheimer’s and Mental Illness Linked to Brain Changes at Birth http://www.sciencedaily.com/releases/2013/01/130102205459.htm Jan. 2, 2013 — Some brain changes that are found in adults with common gene variants linked to disorders such as Alzheimer’s disease, schizophrenia, and autism … Continue reading

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