Search Results for: neuroinflammation

Neuroinflammation and Autism – Imbalance in GABAergic and glutamatergic synapses as a consequence of neuroinflammation.

GABAergic/glutamatergic imbalance relative to excessive neuroinflammation in autism spectrum disorders  http://www.jneuroinflammation.com/content/11/1/189 Background Autism spectrum disorder (ASD) is characterized by three core behavioral domains: social deficits, impaired communication, and repetitive behaviors. Glutamatergic/GABAergic imbalance has been found in various preclinical models of … Continue reading

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Brain Neuroinflammation and Memory

Brain inflammation dramatically disrupts memory retrieval networks, UCI study finds http://news.uci.edu/press-releases/brain-inflammation-dramatically-disrupts-memory-retrieval-networks-uci-study-finds/ Research sheds light on cognitive losses seen with chemotherapy, autoimmune diseases Irvine, Calif., Sept. 10, 2014 — Brain inflammation can rapidly disrupt our ability to retrieve complex memories of … Continue reading

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TAK-242 / TLR-4 – Neuroinflammation

Toll-like 4 receptor inhibitor TAK-242 decreases neuroinflammation in rat brain frontal cortex after stress http://www.jneuroinflammation.com/content/11/1/8/abstract The innate immune response is the first line of defence against invading microorganisms and it is also activated in different neurologic/neurodegenerative pathological scenarios. As a … Continue reading

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Biomarkers of Neuroinflammation – Autism – GABA, Oxytocin and IFI16

Association of social and cognitive impairment and biomarkers in autism spectrum disorders http://www.jneuroinflammation.com/content/11/1/4/abstract# Full Paper at Link Objectives The neurological basis for autism is still not fully understood, and the role of the interaction between neuro-inflammation and neurotransmission impairment needs … Continue reading

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Neuroinflammation in Autism – Mouse Model

Altered Peripheral and Central Inflammatory Responses in a Mouse Model of Autism. http://www.ncbi.nlm.nih.gov/pubmed/24124122 Abstract Increasing clinical and experimental evidence links immune and inflammatory alterations with the pathogenesis of autism spectrum disorders (ASD). Autistic individuals show signs of neuroinflammation, altered inflammatory … Continue reading

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Neuroinflammation in Autism

Neuroinflammation in autism spectrum disorders http://www.jneuroinflammation.com/content/9/1/265/abstract The complete article is available as a provisional PDF. The fully formatted PDF and HTML versions are in production. Abstract (provisional) Objectives The neurobiological basis for autism remains poorly understood. However, research suggests that … Continue reading

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Immune System, Epilepsy and the Eye

Immune response in the eye following epileptic seizures http://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-016-0618-3   Abstract Background Epileptic seizures are associated with an immune response in the brain. However, it is not known whether it can extend to remote areas of the brain, such as … Continue reading

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Environment x Genes – Fungicides and Autism

Could a new class of fungicides play a role in autism, neurodegenerative diseases? http://news.unchealthcare.org/news/2016/march/could-a-new-class-of-fungicides-play-a-role-in-autism-neurodegenerative-diseases A new UNC School of Medicine study shows how chemicals designed to protect crops can cause gene expression changes in mouse brain cells that look strikingly … Continue reading

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Microglia, Inflammation, the Immune System, Cerebral Palsy and Autism

Microglial migration and interactions with dendrimer nanoparticles are altered in the presence of neuroinflammation. http://www.ncbi.nlm.nih.gov/pubmed/27004516  Abstract BACKGROUND: Microglial cells have been implicated in neuroinflammation-mediated injury in the brain, including neurodevelopmental disorders such as cerebral palsy (CP) and autism. Pro-inflammatory activation … Continue reading

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Autism – Social Deficits driven by expression of Immune Gene Networks

Association of brain immune genes with social behavior of inbred mouse strains  http://www.jneuroinflammation.com/content/12/1/75  Background Social deficit is one of the core symptoms of neuropsychiatric diseases, in which immune genes play an important role. Although a few immune genes have been … Continue reading

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