Search Results for: mTor immune

Regulation of Immune Responses by mTOR

Regulation of Immune Responses by mTOR http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616892/ mTOR is an evolutionarily conserved serine/threonine kinase that plays a central role in integrating environmental cues in the form of growth factors, amino acids, and energy. In the study of the immune system, … Continue reading

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mTor Pathway – Is this the unifying factor in Autism , Epilpesy, Immune Dysfunction and Allergy ?

Children with Autism Have Extra Synapses in Brain newsroom.cumc.columbia.edu May be possible to prune synapses with drug after diagnosis NEW YORK, NY (August 21, 2014) — Children and adolescents with autism have a surplus of synapses in the brain, and … Continue reading

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mTORC – Immune Signalling and Metabolic Programming

mTORC1 couples immune signals and metabolic programming to establish Treg-cell function http://www.nature.com/nature/journal/v499/n7459/full/nature12297.html?WT.ec_id=NATURE-20130725 The mechanistic target of rapamycin (mTOR) pathway integrates diverse environmental inputs, including immune signals and metabolic cues, to direct T-cell fate decisions1. The activation of mTOR, which is … Continue reading

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Immune Protiens (MHC1) – Autism, Alzheimer’s and Diabetes

Immune proteins moonlight to regulate brain-cell connections  http://www.princeton.edu by Morgan Kelly, Office of Communications When it comes to the brain, “more is better” seems like an obvious assumption. But in the case of synapses, which are the connections between brain … Continue reading

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AMPK, AKT/mTOR pathways and neuroinflammatory cytokine release in Epilepsy

Early molecular and behavioral response to lipopolysaccharide in the WAG/Rij rat model of absence epilepsy and depressive-like behavior, involves interplay between AMPK, AKT/mTOR pathways and neuroinflammatory cytokine release. http://www.ncbi.nlm.nih.gov/pubmed/24998197 Abstract The mammalian target of rapamycin (mTOR) pathway has been recently … Continue reading

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mTOR pathway : New Research Findings II

Maintaining immune balance involves an unconventional mechanism of T cell regulation http://www.stjude.org/stjude/v/index.jsp?vgnextoid=4473f85a595af310VgnVCM100000290115acRCRD&vgnextchannel=708113c016118010VgnVCM1000000e2015acRCRD St. Jude Children’s Research Hospital study challenges prior understanding of the process regulating specialized T cells that are essential for a balanced immune system. New findings from St. … Continue reading

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mTOR pathway : New Research Findings

mTORC1 couples immune signals and metabolic programming to establish Treg-cell function http://www.nature.com/nature/journal/vaop/ncurrent/full/nature12297.html?WT.ec_id=NATURE-20130704 The mechanistic target of rapamycin (mTOR) pathway integrates diverse environmental inputs, including immune signals and metabolic cues, to direct T-cell fate decisions1. The activation of mTOR, which is … Continue reading

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Glucose Metabolism, Cytotoxic T lymphocytes and mTOR

Cellular Metabolism Arms T Cells to Battle Viruses and Tumors http://www.sciencedaily.com/releases/2012/12/121224113420.htm Dec. 24, 2012 — New research demonstrates that the cellular metabolism of certain immune cells is closely linked to their function, which includes protecting against viral infections and the … Continue reading

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mTOR and Autism

Autism-related deficits via dysregulated eIF4E-dependent translational control. http://www.ncbi.nlm.nih.gov/pubmed/23172145 Abstract Hyperconnectivity of neuronal circuits due to increased synaptic protein synthesis is thought to cause autism spectrum disorders (ASDs). The mammalian target of rapamycin (mTOR) is strongly implicated in ASDs by means … Continue reading

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Allergy of the brain ? A New Perspective on Autism.

Is a Subtype of Autism an Allergy of the Brain? http://www.ncbi.nlm.nih.gov/pubmed/23688533 Molecular Immunopharmacology and Drug Discovery Laboratory, Department of Molecular Physiology and Pharmacology, Tufts University School of Medicine, Boston Abstract BACKGROUND: Autism spectrum disorders (ASDs) are characterized by deficits in … Continue reading

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