Search Results for: immune activation

Early Life Immune Activation and ASD

Perinatal Immune Activation Produces Persistent Sleep Alterations and Epileptiform Activity in Male Mice. https://www.ncbi.nlm.nih.gov/pubmed/28984294# Abstract Increasing evidence suggests a role for inflammation in neuropsychiatric conditions including autism spectrum disorder (ASD). Previous work in rodents has established that immune activation during … Continue reading

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Maternal Immune Activation and Neuropathology in Nonhuman Primates

Preliminary evidence of neuropathology in nonhuman primates prenatally exposed to maternal immune activation. http://www.ncbi.nlm.nih.gov/pubmed/25816799 Abstract Maternal infection during pregnancy increases the risk for neurodevelopmental disorders in offspring. Rodent models have played a critical role in establishing maternal immune activation (MIA) … Continue reading

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Maternal Immune Activation and Hyperactive Immune Response

Maternal Lipopolysaccharide Exposure Promotes Immunological Functional Changes in Adult Offspring CD4+ T Cells. http://www.ncbi.nlm.nih.gov/pubmed/25640465 Abstract PROBLEM: Maternal immune activation (MIA) is a risk factor for autism and schizophrenia. However, how MIA affects offspring immune function remains unknown. METHOD OF STUDY: … Continue reading

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Maternal Immune Activation – IL-6 and Disruption of Brain Development in Autism

Metabolic consequences of interleukin-6 challenge in developing neurons and astroglia http://www.jneuroinflammation.com/content/11/1/183 Abstract Background Maternal immune activation and subsequent interleukin-6 (IL-6) induction disrupt normal brain development and predispose the offspring to developing autism and schizophrenia. While several proteins have been identified … Continue reading

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Maternal Immune Activation and Molecular Cascade

Metabolic consequences of interleukin-6 challenge in developing neurons and astroglia. http://www.ncbi.nlm.nih.gov/pubmed/25374324 Maternal immune activation and subsequent interleukin-6 (IL-6) induction disrupt normal brain development and predispose the offspring to developing autism and schizophrenia. While several proteins have been identified as having … Continue reading

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Breakthrough Autism Story 2014 – Maternal Immune Activation in Autism, Schizophrenia and Epilepsy. Emerging evidence in Alzheimer’s and Parkinson’s Disease

Maternal immune activation and abnormal brain development across CNS disorders http://www.nature.com/nrneurol/journal/vaop/ncurrent/full/nrneurol.2014.187.html Epidemiological studies have shown a clear association between maternal infection and schizophrenia or autism in the progeny. Animal models have revealed maternal immune activation (mIA) to be a profound … Continue reading

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Autism , Maternal Immune Activation and Gender

Gender-Dependent Effects of Maternal Immune Activation on the Behavior of Mouse Offspring. http://www.ncbi.nlm.nih.gov ¬†Abstract Autism spectrum disorders are neurodevelopmental disorders characterized by two core symptoms; impaired social interactions and communication, and ritualistic or repetitive behaviors. Both epidemiological and biochemical evidence … Continue reading

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Immune imbalance – Maternal Immune Activation – Schizophrenia

Cytokine pathway disruption in a mouse model of schizophrenia induced by Munc18-1a overexpression in the brain http://www.jneuroinflammation.com/content/11/1/128/abstract Background An accumulating body of evidence points to the significance of neuroinflammation and immunogenetics in schizophrenia, and an imbalance of cytokines in the … Continue reading

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Immune Activation – Maternal Iron Deficiency – Altered Brain Development

Additive effects of maternal iron deficiency and prenatal immune activation on adult behaviors in rat offspring. http://www.ncbi.nlm.nih.gov/pubmed/24930842 Abstract Both iron deficiency (ID) and infection are common during pregnancy and studies have described altered brain development in offspring as a result … Continue reading

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The Influenza Iceberg – Implications for Maternal Immune Activation in Autism

Symptoms Just Tip of Flu Iceberg http://www.medpagetoday.com/Pulmonology/URIstheFlu/44804 Published: Mar 17, 2014 | Updated: Mar 18, 2014 By¬†Crystal Phend, Senior Staff Writer, MedPage Today Three-quarters of seasonal and pandemic influenza infections never caused symptoms, a population-based comparison of serologic and weekly … Continue reading

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