Dysregulation of Innate Immune Response in Autism.

Transcriptome analysis reveals dysregulation of innate immune response genes and neuronal activity-dependent genes in autism.

http://www.ncbi.nlm.nih.gov/pubmed/25494366

Abstract

Recent studies of genomic variation associated with autism have suggested the existence of extreme heterogeneity. Large-scale transcriptomics should complement these results to identify core molecular pathways underlying autism.

Here we report results from a large-scale RNA sequencing effort, utilizing region-matched autism and control brains to identify neuronal and microglial genes robustly dysregulated in autism cortical brain.

Remarkably, we note that a gene expression module corresponding to M2-activation states in microglia is negatively correlated with a differentially expressed neuronal module, implicating dysregulated microglial responses in concert with altered neuronal activity-dependent genes in autism brains. These observations provide pathways and candidate genes that highlight the interplay between innate immunity and neuronal activity in the aetiology of autism.

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This entry was posted in Autism, Immune System, Inflammation. Bookmark the permalink.

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