Sensory Abnormalities, Propionic Acid , Autism and the Double Hit Hypothesis

Sexually dimorphic effects of prenatal exposure to lipopolysaccharide, and prenatal and postnatal exposure to propionic acid, on acoustic startle response and prepulse inhibition in adolescent rats: Relevance to autism spectrum disorders.

http://www.ncbi.nlm.nih.gov/pubmed/25300465

Abstract

Potential environmental risk factors for autism spectrum disorders (ASD) include viral/bacterial infection and an altered microbiome composition.

The present study investigated whether administration of immune and gastrointestinal factors during gestation and early life altered startle response and prepulse inhibition in adolescent offspring using lipopolysaccharide (LPS), a bacterial mimetic, and propionic acid (PPA), a short chain fatty acid and metabolic product of antibiotic resistant enteric bacteria.

Pregnant Long-Evans rats were injected once a day with PPA (500mg/kg SC) on G12-16, LPS (50μg/kg SC) on G15-16, or vehicle control on G12-16 or G15-16. Male and female offspring were injected with PPA (500mg/kg SC) or vehicle twice a day, every second day from postnatal days 10-18. Acoustic startle and prepulse inhibition were measured on postnatal days 45, 47, 49, and 51.

Prenatal and postnatal treatments altered startle behavior in a sex-specific manner.

Prenatal LPS treatment produced hyper-sensitivity to acoustic startle in males, but not females and did not alter prepulse inhibition.

Subtle alterations in startle responses that disappeared with repeated trials occurred with prenatal PPA and postnatal PPA treatment in both male and female offspring.

Prenatal PPA treatment decreased prepulse inhibition in females, but not males.

Lastly, females receiving a double hit of PPA, prenatal and postnatal, showed sensitization to acoustic startle, providing evidence for the double hit hypothesis.

The current study supports the hypotheses that immune activation and metabolic products of enteric bacteria may alter development and behavior in ways that resemble sensory abnormalities observed in ASD.

Copyright © 2014. Published by Elsevier B.V.

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This entry was posted in Autism, Bacteria, bowel disease, co-morbid, Environment, Gut, IBD, Immune System, Inflammation, Toxins. Bookmark the permalink.

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