Daily Archives: July 10, 2014

AMPK, AKT/mTOR pathways and neuroinflammatory cytokine release in Epilepsy

Early molecular and behavioral response to lipopolysaccharide in the WAG/Rij rat model of absence epilepsy and depressive-like behavior, involves interplay between AMPK, AKT/mTOR pathways and neuroinflammatory cytokine release. http://www.ncbi.nlm.nih.gov/pubmed/24998197 Abstract The mammalian target of rapamycin (mTOR) pathway has been recently … Continue reading

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mTOR Pathway – Autism and a broader spectrum of Epilepsy

Evidence for mTOR pathway activation in a spectrum of epilepsy-associated pathologies. http://www.ncbi.nlm.nih.gov/pubmed/25005575 INTRODUCTION: Activation of the mTOR pathway has been linked to the cytopathology and epileptogenicity of malformations, specifically Focal Cortical Dysplasia (FCD) and Tuberous Sclerosis (TSC). Experimental and clinical … Continue reading

Posted in Autism, co-morbid, Environment, epilepsy, Treatment | Leave a comment