Autoimmune Etiology and Epilepsy – 5x Risk in Children

Population-Level Evidence for an Autoimmune Etiology of Epilepsy.

http://www.ncbi.nlm.nih.gov/pubmed/24687183

Abstract

IMPORTANCE

Epilepsy is a debilitating condition, often with neither a known etiology nor an effective treatment. Autoimmune mechanisms have been increasingly identified.

OBJECTIVE To conduct a population-level study investigating the relationship between epilepsy and several common autoimmune diseases.

DESIGN, SETTING, AND PARTICIPANTS

A retrospective population-based study using claims from a nationwide employer-provided health insurance plan in the United States. Participants were beneficiaries enrolled between 1999 and 2006 (N = 2 518 034).

MAIN OUTCOMES AND MEASURES

We examined the relationship between epilepsy and 12 autoimmune diseases: type 1 diabetes mellitus, psoriasis, rheumatoid arthritis, Graves disease, Hashimoto thyroiditis, Crohn disease, ulcerative colitis, systemic lupus erythematosus, antiphospholipid syndrome, Sjögren syndrome, myasthenia gravis, and celiac disease.

RESULTS

The risk of epilepsy was significantly heightened among patients with autoimmune diseases (odds ratio, 3.8; 95% CI, 3.6-4.0; P < .001)

and was especially pronounced in children (5.2; 4.1-6.5; P < .001).

Elevated risk was consistently observed across all 12 autoimmune diseases.

CONCLUSIONS AND RELEVANCE

Epilepsy and autoimmune disease frequently co-occur; patients with either condition should undergo surveillance for the other. The potential role of autoimmunity must be given due consideration in epilepsy so that we are not overlooking a treatable cause.

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Further Readings of Interest

Combining two genome analysis approaches supports immune system contribution to autism

http://www.massgeneral.org/about/pressrelease.aspx?id=1531

Comorbidity Clusters in Autism Spectrum Disorders: An Electronic Health Record Time-Series Analysis.

http://www.ncbi.nlm.nih.gov/pubmed/24323995

The Co-Morbidity Burden of Children and Young Adults with Autism Spectrum Disorders

http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0033224

Seizures

https://asdresearchinitiative.wordpress.com/?s=seizures

Epilepsy

https://asdresearchinitiative.wordpress.com/?s=epilepsy

Autoimmune

https://asdresearchinitiative.wordpress.com/?s=autoimmune

Comorbidity of allergic and autoimmune diseases in patients with autism spectrum disorder: A nationwide population-based study

http://www.sciencedirect.com/science/article/pii/S1750946712001018

Previous clinical and genetic studies have suggested autism spectrum disorders (ASDs) is associated with immunological abnormalities involving cytokines, immunoglobulins, inflammation, and cellular immunity, but epidemiological reports are still limited.

Patients with ASDs were identified in the National Health Insurance Database from 1996 to 2010, and compared with age and gender-matched controls (1:4) in an investigation of the association between ASDs and allergic/autoimmune diseases.

A total of 1596 patients with ASDs were identified, and were found to have a significantly higher prevalence of allergic and autoimmune diseases than the control group.

Patients with ASDs had increased risks of

asthma (OR = 1.74, 95%CI = 1.51–1.99),

allergic rhinitis (OR = 1.70, 95%CI = 1.51–1.91),

atopic dermatitis (OR = 1.52, 95%CI = 1.30–1.78),

urticaria (OR = 1.38, 95%CI = 1.12–1.69) and

type 1 diabetes (OR = 4.00, 95%CI = 1.00–16.00), and a trend toward increasing comorbidity with

Crohn’s disease (OR = 1.46, 95%CI = 0.90–2.35).

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This entry was posted in Allergy, Asthma, Autism, co-morbid, Depression, diabetes, Environment, Epidemiology, epilepsy, Gut, Immune System, Inflammation, Muscular Dystrophy, Neurology, Physiology, Schizophrenia, Treatment. Bookmark the permalink.

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