Paracetemol and Eczema

Risk factors for eczema in infants born in Cuba: a population-based cross-sectional study


There is a concern that allergic disease in childhood is higher than expected in Cuba. The aim of this study was to determine the risk factors for eczema of infants aged 12-15 months living in Havana.


We used a cross-sectional epidemiological study design. Data on eczema symptoms and a wide range of lifestyle factors were collected by researcher administered questionnaires.


Data were collected on 1956 children (96% response rate), of whom 672 (34%) were reported as having had eczema.

Independent risk factors for eczema included young maternal age (adjusted odds ratio (OR) 0.98 per additional year of age; 95% confidence interval (CI) 0.97-0.99),

child’s weight (OR 1.13 per additional kg; 95% CI: 1.03-1.25),

insect sting allergy (OR 2.11; 95% CI: 1.33-3.35),

rodents in the home (OR 1.39; 95% CI: 1.10-1.76),

attendance at childcare facilities (OR 1.34: 95% CI: 1.05-1.70) and

self-reported mould in the home (OR 1.23; 95% CI: 1.07-1.41).

Infant exposure to paracetamol was associated with an increased risk of eczema even after adjustment for wheeze (OR 1.22; 95% CI: 1.03-1.46).


Despite a very different culture and environment, the consistency of these findings with those from more economically developed countries suggests potential causal associations. The association with paracetamol, even after adjustment for wheeze, suggests that intervention studies are required in young infants, to ascertain if this commonly used anti-pyretic medication increases allergic disease.

This entry was posted in Asthma, Autism, Gut, Immune System, Inflammation. Bookmark the permalink.

Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s