Microbiota Modulate Behavioral and Physiological Abnormalities Associated with Neurodevelopmental Disorders
Full Paper at Link
- The MIA model recapitulates GI comorbidities linked to a subset of ASD individuals
- Targeting the microbiota treats specific GI and behavioral symptoms
- Gut microbes regulate metabolites that alter behavior in animals
- Microbiota may contribute to the pathophysiology of neurodevelopmental disorders
Neurodevelopmental disorders, including autism spectrum disorder (ASD), are defined by core behavioral impairments; however, subsets of individuals display a spectrum of gastrointestinal (GI) abnormalities.
We demonstrate GI barrier defects and microbiota alterations in the maternal immune activation (MIA) mouse model that is known to display features of ASD.
Oral treatment of MIA offspring with the human commensal Bacteroides fragilis corrects gut permeability, alters microbial composition, and ameliorates defects in communicative, stereotypic, anxiety-like and sensorimotor behaviors.
MIA offspring display an altered serum metabolomic profile, and B. fragilis modulates levels of several metabolites. Treating naive mice with a metabolite that is increased by MIA and restored by B. fragilis causes certain behavioral abnormalities, suggesting that gut bacterial effects on the host metabolome impact behavior.
Taken together, these findings support a gut-microbiome-brain connection in a mouse model of ASD and identify a potential probiotic therapy for GI and particular behavioral symptoms in human neurodevelopmental disorders.
Further Readings of Interest
Paul Patterson Blog
Activation of the Maternal Immune System During Pregnancy Alters Behavioral Development of Rhesus Monkey Offspring.
Paul Patterson and colleagues Pubmed