Breakthrough in Autism Treatment – Gut, Microbes and Probiotics

Microbiota Modulate Behavioral and Physiological Abnormalities Associated with Neurodevelopmental Disorders

http://www.cell.com/abstract/S0092-8674%2813%2901473-6

Full Paper at Link

  • Highlights
  • The MIA model recapitulates GI comorbidities linked to a subset of ASD individuals
  • Targeting the microbiota treats specific GI and behavioral symptoms
  • Gut microbes regulate metabolites that alter behavior in animals
  • Microbiota may contribute to the pathophysiology of neurodevelopmental disorders

Summary

Neurodevelopmental disorders, including autism spectrum disorder (ASD), are defined by core behavioral impairments; however, subsets of individuals display a spectrum of gastrointestinal (GI) abnormalities.

We demonstrate GI barrier defects and microbiota alterations in the maternal immune activation (MIA) mouse model that is known to display features of ASD.

Oral treatment of MIA offspring with the human commensal Bacteroides fragilis corrects gut permeability, alters microbial composition, and ameliorates defects in communicative, stereotypic, anxiety-like and sensorimotor behaviors.

MIA offspring display an altered serum metabolomic profile, and B. fragilis modulates levels of several metabolites. Treating naive mice with a metabolite that is increased by MIA and restored by B. fragilis causes certain behavioral abnormalities, suggesting that gut bacterial effects on the host metabolome impact behavior.

Taken together, these findings support a gut-microbiome-brain connection in a mouse model of ASD and identify a potential probiotic therapy for GI and particular behavioral symptoms in human neurodevelopmental disorders.

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Further Readings of Interest

Paul Patterson Blog

http://infectiousbehavior.wordpress.com/

Activation of the Maternal Immune System During Pregnancy Alters Behavioral Development of Rhesus Monkey Offspring.

http://www.ncbi.nlm.nih.gov/pubmed/24011823

Paul Patterson and colleagues Pubmed

http://www.ncbi.nlm.nih.gov/pubmed/?term=Patterson+PH[Author]

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This entry was posted in Autism, co-morbid, Depression, Environment, Gut, Immune System, Inflammation, Mice, Treatment. Bookmark the permalink.

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