Epilepsy, Autism and Behaviors

The association between epilepsy and autism symptoms and maladaptive behaviors in children with autism spectrum disorder.

http://www.ncbi.nlm.nih.gov/pubmed/24165273

Abstract

Epilepsy is common in children with autism spectrum disorder (ASD) but little is known about how seizures impact the autism phenotype.

The association between epilepsy and autism symptoms and associated maladaptive behaviors was examined in 2,645 children with ASD, of whom 139 had epilepsy, from the Simons Simplex Collection.

Children with ASD and epilepsy had significantly more autism symptoms and maladaptive behaviors than children without epilepsy.

However, after adjusting for IQ, only hyperactivity symptoms remained significantly increased (13% higher) in the epilepsy group.

Among children with ASD without co-occurring intellectual disability, children with epilepsy had significantly more irritability (20% higher) and hyperactivity (24% higher) symptoms.

This is the largest study to date comparing the autism phenotype in children with ASD with and without epilepsy.

Children with ASD and epilepsy showed greater impairment than children without epilepsy, which was mostly explained by the lower IQ of the epilepsy group.

These findings have important clinical implications for patients with ASD.

Advertisements
This entry was posted in Autism, co-morbid, Neurology, Physiology, Treatment. Bookmark the permalink.

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s