Daily Archives: October 7, 2013

Asperger Syndrome – Differences in White Matter Fibre Tract Organization

Increased Coherence of White Matter Fiber Tract Organization in Adults with Asperger Syndrome: A Diffusion Tensor Imaging Study. http://www.ncbi.nlm.nih.gov/pubmed/24089369 Abstract To investigate whether there are global white matter (WM) differences between autistic and healthy adults, we performed diffusion tensor imaging … Continue reading

Posted in Autism, co-morbid, Neurology | Leave a comment

Shank3 deficiency on the NMDA-type glutamate receptor, a key player in Autism ?

Shank3 Deficiency Induces NMDA Receptor Hypofunction via an Actin-Dependent Mechanism. http://www.ncbi.nlm.nih.gov/pubmed/24089484 Abstract Shank3, which encodes a scaffolding protein at glutamatergic synapses, is a genetic risk factor for autism. In this study, we examined the impact of Shank3 deficiency on the … Continue reading

Posted in Autism, Epigenetics, Genetics | Leave a comment

Inflammation, Secondary Insults : Schizophrenia and Autism

Combination of prenatal immune challenge and restraint stress affects prepulse inhibition and dopaminergic/GABAergic markers. http://www.ncbi.nlm.nih.gov/pubmed/23697796 Abstract Gestational immune challenge with the viral-like antigen poly I:C is a well-established neurodevelopmental model of schizophrenia. However, exposure to inflammation during early life may … Continue reading

Posted in Autism, co-morbid, Environment, Immune System, Inflammation, Mice, Neurology, Physiology, Schizophrenia | Leave a comment

Changes in Striatum Development in Autism

Changes in the Development of Striatum Are Involved in Repetitive Behavior in Autism. http://www.ncbi.nlm.nih.gov/pubmed/24090791 Abstract BACKGROUND: Repetitive behavior is a core feature of autism and has been linked to differences in striatum. In addition, the brain changes associated with autism … Continue reading

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anti-NMDA receptor encephalitis and Regressive Autism

Anti-N-Methyl-D-Aspartate (NMDA) Receptor Encephalitis: An Unusual Cause of Autistic Regression in a Toddler. http://www.ncbi.nlm.nih.gov/pubmed/24092894 Abstract Anti N-methyl-d-aspartate (NMDA) receptor encephalitis in children is associated with psychiatric changes, seizures, and dyskinesias. We present the first report of autistic regression in a … Continue reading

Posted in Autism, co-morbid, Environment, Immune System, Inflammation, Neurology, Physiology, Treatment | Leave a comment