Fecal Transplant, Now in Pill Form
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SAN FRANCISCO — Gel caps containing concentrated fecal microbes stopped recurrent Clostridium difficile infection and were well-tolerated by recipients, researchers reported here.
Among patients with more than three episodes of recurrent C. difficile infection who could not tolerate jejunal catheter or suffered anal incontinence, a single dose of an oral suspension of fecal microbes delivered through several dozen 0.47 mL gel capsules resolved all but one of the recurrent infections with no instances of vomiting after capsule ingestion, according to Thomas Louie, MD, of the University of Calgary in Alberta, Canada, and colleagues.
In the one instance of recurrence, repeat infection following treatment was associated with the patient’s chronic reinfection elsewhere in the body, Louie reported during a press conference at the IDWeek meeting.
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