COX-2 – Schizophrenia – Depression – Inflammation Treatment

The role of anti-inflammatory treatment in psychiatric disorders.

http://www.ncbi.nlm.nih.gov/pubmed/24048400

Abstract

Anti-inflammatory treatment could be expected to show positive effects in the subgroup of psychiatric patients who show signs of inflammation, i.e. an increase in proinflammatory cytokines and PGE2.

Cyclooxygenase-2 (COX-2) not only reduces the levels of proinflammatory cytokines, but also affects glutamatergic neurotransmission and tryptophan/kynurenine metabolism.

In the meantime, several studies have been performed with the COX-2 inhibitor celecoxib in schizophrenia; the studies found a therapeutic effect, mainly in the early stages of the disorder.

We were able to demonstrate a statistically significant therapeutic effect of celecoxib on depressive symptoms in a study in patients with major depression (MD).

Another study in fifty patients with MD also showed a statistically significant better outcome with celecoxib. This paper will discuss immune-based therapeutic approaches in both schizophrenia and depression.

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Further Readings of Interest

Full Paper at link

www.hdbp.org/psychiatria_danubina/pdf/…/dnb_vol25_no3_292.pdf

Cox-2

https://asdresearchinitiative.wordpress.com/?s=cox-2

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This entry was posted in Autism, Immune System, Inflammation, Schizophrenia, Treatment. Bookmark the permalink.

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