Combined prenatal and postnatal butyl paraben exposure produces autism-like symptoms in offspring: comparison with valproic acid autistic model.
The aim of this work is to evaluate the impact of butyl paraben (BP) in brain of the pups developed for mothers administered BP from early pregnancy till weaning and its effect on studying the behavior, brain neurotransmitters and brain derived neurotrophic factor BDNF via comparing the results with valproic acid (VA) autistic- rat model preparing by a single oral injection dose of VA (800 mg/kg b.wt) at the 12.5 day of gestation.
Butyl paraben was orally and subcutaneously administered (200 mg/kg b.wt) to pregnant rats from gestation day 1 to lactation day 21. The offspring male rats were subjected at the last 3 days of lactation to morris water maze and three chamber sociability test then decapitated and brain was excised and dissected to the cortex, hippocampus, cerebellum, midbrain and pons for determination of norepinephrine, dopamine and serotonin (NE, DA and 5-HT) and cortex amino acids and whole brain BDNF.
The results showed similar social and learning and memory behavioral deficits in VA rat model and the butyl paraben offspring in comparison with the controls.
Also, a some similar alterations were observed in monoamine content, amino acids and BDNF factor in the autistic-like model and butyl paraben offspring in comparison with the controls.
Notably, hippocampus and pons NE, midbrain DA, hippocampus and midbrain 5-HT, and frontal cortex GABA and asparagine.
These data suggest that prenatal exposure to butyl paraben induced neuro-developmental disorders similar to some of the neurodevelopmental disorders observed in the VA model of autism.
Further Readings of Interest
Butylparaben is one of the most commonplace bactericidal/fungicidal additives to cosmetics, probably due to its low cost, and efficiency as a microbial agent. It is reported by the EWG to be found in almost 3000 cosmetic products including eye shadow, facial moisturizer/treatment, anti-aging cream, foundation, and sunscreen. In most cosmetics paraben is used at low levels, ranging from 0.01 to 0.3%.
Numerous members of the paraben family are found in fruit and vegetable products, such as barley, flax seed, and grapes. Butylparaben can also be found in low concentrations in liquid and solid medication suspensions, such as tylenol (acetaminophen) and ibuprofen. In the paraben family, butylparaben appears to be the best antifungal agent. It is particularly active against molds and yeasts, and less active against bacteria.