Maternal Antibodies, Social Behavior and Autism

Maternal antibodies from mothers of children with autism alter brain growth and social behavior development in the rhesus monkey

http://www.nature.com/tp/journal/v3/n7/full/tp201347a.html

Antibodies directed against fetal brain proteins of 37 and 73 kDa molecular weight are found in approximately 12% of mothers who have children with autism spectrum disorder (ASD), but not in mothers of typically developing children.

This finding has raised the possibility that these immunoglobulin G (IgG) class antibodies cross the placenta during pregnancy and impact brain development, leading to one form of ASD.

We evaluated the pathogenic potential of these antibodies by using a nonhuman primate model.

IgG was isolated from mothers of children with ASD (IgG-ASD) and of typically developing children (IgG-CON).

The purified IgG was administered to two groups of female rhesus monkeys (IgG-ASD; n=8 and IgG-CON; n=8) during the first and second trimesters of pregnancy.

Another control group of pregnant monkeys (n=8) was untreated.

Brain and behavioral development of the offspring were assessed for 2 years.

Behavioral differences were first detected when the macaque mothers responded to their IgG-ASD offspring with heightened protectiveness during early development.

As they matured, IgG-ASD offspring consistently deviated from species-typical social norms by more frequently approaching familiar peers. The increased approach was not reciprocated and did not lead to sustained social interactions.

Even more striking, IgG-ASD offspring displayed inappropriate approach behavior to unfamiliar peers, clearly deviating from normal macaque social behavior.

Longitudinal magnetic resonance imaging analyses revealed that male IgG-ASD offspring had enlarged brain volume compared with controls.

White matter volume increases appeared to be driving the brain differences in the IgG-ASD offspring and these differences were most pronounced in the frontal lobes.

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This entry was posted in Autism, co-morbid, Environment, Immune System, Inflammation, Treatment. Bookmark the permalink.

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