Missing Link in Autoimmunity and Autism

The “missing link” in autoimmunity and autism: Extracellular mitochondrial components secreted from activated live mast cells.

http://www.ncbi.nlm.nih.gov/pubmed/23831684

Abstract

Autoimmune diseases continue to increase, but the reason(s) remain obscure and infections have not proven to be major contributors.

Mast cells are tissue immune cells responsible for allergies, but have been increasingly shown to be involved in innate and acquired immunity, as well as inflammation. This involvement is possible because of their ability to release multiple mediators in response to a great variety of triggers.

We recently published that activation of mast cells is accompanied by mitochondrial fission and translocation to the cell surface from where they secrete at least ATP and DNA outside the cell without cell damage. These extracellular mitochondrial components are misconstrued by the body as “innate pathogens” leading to powerful autocrine and paracrine auto-immune/auto-inflammatory responses.

We also showed that mitochondrial DNA is increased in the serum of young children with autism spectrum disorders (ASD), a condition that could involve “focal brain allergy/encephalitits.”

Blocking the secretion of extracellular mitochondrial components could present unique possibilities for therapy of ASD and other autoimmune diseases. Unique formulation of the flavonoid luteolin offers unique advantages.

Advertisements
This entry was posted in Allergy, Asthma, Autism, co-morbid, diabetes, Environment, Immune System, Inflammation, Neurology, Physiology, Treatment. Bookmark the permalink.

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s