Gut metagenome in European women with normal, impaired and diabetic glucose control
Type 2 diabetes (T2D) is a result of complex gene–environment interactions, and several risk factors have been identified, including age, family history, diet, sedentary lifestyle and obesity.
Statistical models that combine known risk factors for T2D can partly identify individuals at high risk of developing the disease. However, these studies have so far indicated that human genetics contributes little to the models, whereas socio-demographic and environmental factors have greater influence1.
Recent evidence suggests the importance of the gut microbiota as an environmental factor, and an altered gut microbiota has been linked to metabolic diseases including obesity2, 3, diabetes4 and cardiovascular disease5.
Here we use shotgun sequencing to characterize the faecal metagenome of 145 European women with normal, impaired or diabetic glucose control.
We observe compositional and functional alterations in the metagenomes of women with T2D, and develop a mathematical model based on metagenomic profiles that identified T2D with high accuracy.
We applied this model to women with impaired glucose tolerance, and show that it can identify women who have a diabetes-like metabolism. Furthermore, glucose control and medication were unlikely to have major confounding effects.
We also applied our model to a recently described Chinese cohort4 and show that the discriminant metagenomic markers for T2D differ between the European and Chinese cohorts. Therefore, metagenomic predictive tools for T2D should be specific for the age and geographical location of the populations studied.
Further Readings of Interest
Gut microbes again linked to diabetes — but geography matters
“Particular combinations of bacteria in the human digestive system can identify patients who have or are likely to develop Type 2 diabetes, scientists reported Wednesday in the online edition of the journal Nature.
But the precise combinations of microbes that influence development of the disease may vary among patients of different ages, sexes and ethnicities, the Swedish and Danish researchers said — which means that more study will be needed to use bacteria to diagnose diabetes in people everywhere.”
More at Link