IMFAR 2013 – Non Human Primate Maternal Immune Activation – UC Davis

A Nonhuman Primate Model of Maternal Immune Activation

https://imfar.confex.com/imfar/2013/webprogram/Paper13364.html

M. D. Bauman, Psychiatry and Behavioral Sciences, UC Davis, Sacramento, CA

Background:

Maternal infection during pregnancy is associated with an increased risk of having a child later develop a neurodevelopmental disorder, such as autism or schizophrenia.

In a mouse model of maternal immune activation (MIA), administration of the viral mimic dsRNA poly(I:C) to pregnant dams results in offspring with increased anxiety and repetitive behaviors as well as deficits in social interaction and communication.

Objectives:

To further evaluate this risk factor, we have adapted the rodent polyI:C model for use in the nonhuman primate. 

Methods:

A modified form of poly(I:C) was delivered to pregnant rhesus monkeys (Macaca mulatta) at the end of either the first or second trimester.  A separate control group of pregnant rhesus monkeys received saline injections at these time points. Behavioral development of the MIA-exposed macaque offspring was then systematically evaluated for the first 4 years of life.

Results:

MIA-exposed macaque offspring demonstrate atypical repetitive behaviors, vocalizations and social interactions.

Conclusions:

MIA in the nonhuman primate model was associated with alterations in brain, behavior and immunological development that resemble features of human neurodevelopmental disorders.

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This entry was posted in Autism, co-morbid, Depression, Environment, Immune System, Inflammation, Neurology, Physiology, Schizophrenia, Treatment. Bookmark the permalink.

One Response to IMFAR 2013 – Non Human Primate Maternal Immune Activation – UC Davis

  1. phpatterson says:

    This work has been submitted for publication, so the details may be publicly available before too long. This will be the first of a series of papers characterizing this non-human primate model. Thx for picking up on it, and our other abstract as well! Cheers, PHP

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