A New Shift – Tom Insel TEDx – Caltech

Interesting, but long overdue dialogue on how we should view “Behavioral Disorders” with a focus on themes such as Schizophrenia and Early “Intervention”.


*50% of a large range of ‘mental disorders’ / ‘behavioral disorders’ onset before age 14 (4.50)

* 75% onset before age 24 (5.10)

“The most important transformation is a conceptual one …” (7.00)

” impediments to progress … ” ( Mental disorders / Behavioral Disorders)

Schizophrenia as a Brain Disease (11.20)

Early and Late Grey Matter deficits in Schizophrenia (11.47)

A Developmental model for Schizophrenia (12.23)

For Brain Disorders, behavior is the last thing to change (13.11)

New tools can show us the presence of brain changes long before symptoms emerge (13.25)

Early Detection and Early Intervention will give us the best outcomes.

“If we waited until the heart attack we would be sacrificing 1.1 million lives every year …” (13.52)

“that is precisely what we do today … we wait until the behavior becomes manifest” (13.53)

Thomas R. Insel, M.D., is Director of the National Institute of Mental Health (NIMH), the component of the National Institutes of Health charged with generating the knowledge needed to understand, treat, and prevent mental disorders. His tenure at NIMH has been distinguished by groundbreaking findings in the areas of practical clinical trials, autism research, and the role of genetics in mental illnesses.


This entry was posted in Autism, Environment, Epigenetics, Genetics, Gut, Immune System, Inflammation, Mice, Neurology, Physiology, Schizophrenia, Treatment. Bookmark the permalink.

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