Microglial Activation in Autism

Microglial activation in young adults with autism spectrum disorder.

http://www.ncbi.nlm.nih.gov/pubmed/23404112

CONTEXT

A growing body of evidence suggests that aberrant immunologic systems underlie the pathophysiologic characteristics of autism spectrum disorder (ASD).

However, to our knowledge, no information is available on the patterns of distribution of microglial activation in the brain in ASD.

OBJECTIVES

To identify brain regions associated with excessively activated microglia in the whole brain, and to examine similarities in the pattern of distribution of activated microglia in subjects with ASD and control subjects.

DESIGN

Case-control study using positron emission tomography and a radiotracer for microglia-[11C](R)-(1-[2-chrorophynyl]- N-methyl- N-[1-methylpropyl]-3 isoquinoline carboxamide) ([11C](R)-PK11195). SETTING Subjects recruited from the community.

PARTICIPANTS

Twenty men with ASD (age range, 18-31 years; mean [SD] IQ, 95.9 [16.7]) and 20 age- and IQ-matched healthy men as controls. Diagnosis of ASD was made in accordance with the Autism Diagnostic Observation Schedule and the Autism Diagnostic Interview-Revised.

MAIN OUTCOME MEASURES

Regional brain [11C](R)-PK11195 binding potential as a representative measure of microglial activation.

RESULTS

The [11C](R)-PK11195 binding potential values were significantly higher in multiple brain regions in young adults with ASD compared with those of controls (P < .05, corrected).

Brain regions with increased binding potentials included the cerebellum, midbrain, pons, fusiform gyri, and the anterior cingulate and orbitofrontal cortices.

The most prominent increase was observed in the cerebellum. The pattern of distribution of [11C](R)-PK11195 binding potential values in these brain regions of ASD and control subjects was similar, whereas the magnitude of the [11C](R)-PK11195 binding potential in the ASD group was greater than that of controls in all regions.

CONCLUSIONS

Our results indicate excessive microglial activation in multiple brain regions in young adult subjects with ASD. The similar distribution pattern of regional microglial activity in the ASD and control groups may indicate augmented but not altered microglial activation in the brain in the subjects with ASD.

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This entry was posted in Autism, co-morbid, Environment, Immune System, Inflammation, Neurology, Physiology. Bookmark the permalink.

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