Baby Pigs , Bacteria and Human Health

Bacterial supplement could help young pigs fight disease

http://www.asas.org/membership-services/press-room/press-release-interpretive-summary-archive/bacterial-supplement-could-help-young-pigs-fight-disease

A common type of bacteria may help pigs stay healthy during weaning.

In a study of 36 weanling-age pigs, researchers found that a dose of lipid-producing Rhodococcus opacus bacteria increased circulating triglycerides. Triglycerides are a crucial source of energy for the immune system.

“We could potentially strengthen the immune system by providing this bacterium to animals at a stage when they are in need of additional energy,” said Janet Donaldson, assistant professor in Biological Sciences Mississippi State University. “By providing an alternative energy source, the pigs are most likely going to be able to fight off infections more efficiently.”

Donaldson and other researchers tested R. opacus because the bacterium naturally makes large amounts of triglycerides. Normally, R. opacus would use the triglycerides for its own energy, but a pig can use the triglycerides too.

Jeff Carroll, research leader for the USDA Agricultural Research Service Livestock Issues Research Unit in Lubbock, Texas, said R. opacus could be used sort of like an energy producing probiotic. He said weanling pigs are more susceptible to pathogens and stress because they have to adjust to a new diet and a new environment. To add to the risk, weaning comes at a time when a pig’s immune system is immature. The stress of weaning can lead to reduced feed intake, less available energy and an increased risk of infection.

With an oral supplement of live R. opacus, weanling pigs would have an alternative source of energy. Even if pigs ate less feed, they would still have access to the triglycerides produced by these bacteria. The triglycerides could be used as an energy source during this critical stage of development.

Throughout the experiment, the researchers kept watch for any potential side effects. Donaldson said they saw no negative side effects in the pigs given R. opacus. Because of this success, Donaldson said pig producers might someday use R. opacus on their own farms. She said the bacteria could be provided to pigs through existing watering systems.

The next step in the experiment is to test how pigs given R. opacus react to an immune challenge such as Salmonella. Carroll said he is also curious to see if R. opacus can help calves stay healthy during transport.

“This could potentially be carried over to human health as well,” Donaldson said.

This study was a collaboration between Janet Donaldson at Mississippi State University; Jeff Carroll at USDA-ARS’ Livestock Issues Research Unit; Ty Schmidt at the University of Nebraska, Lincoln; Todd Callaway at USDA-ARS’ Food and Feed Safety Research Unit; Jessica Grissett at Mississippi State University; and Nicole Burdick Sanchez at USDA-ARS’ Livestock Issues Research Unit.

The abstract from this project, titled “Novel Use of Lipid-Producing Bacteria to Increase Circulating Triglycerides in Swine,” is the 2013 recipient of the National Pork Board Swine Industry Award for Innovation. The award will be presented at the 2013 American Society of Animal Science Southern Section Meeting in Orlando, Florida.

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Further Readings of Interest

http://en.wikipedia.org/wiki/Triglyceride

http://www.ncbi.nlm.nih.gov/pubmed?term=Triglyceride%20autism

Alterations in lipid profile of autistic boys: a case control study.

http://www.ncbi.nlm.nih.gov/pubmed/20534328

Department of Food Science, Gangneung-Wonju National University, Gangwon-do, Korea.

Abstract

We hypothesize that autism is associated with alterations in the plasma lipid profile and that some lipid fractions in autistic boys may be significantly different than those of healthy boys.

A matched case control study was conducted with 29 autistic boys (mean age, 10.1 +/- 1.3 years) recruited from a school for disabled children and 29 comparable healthy boys from a neighboring elementary school in South Korea. Fasting plasma total cholesterol (T-Chol), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), the LDL/HDL ratio, and 1-day food intakes were measured.

Multiple regression analyses were performed to assess the association between autism and various lipid fractions.

The mean TG level (102.4 +/- 52.4 vs 70.6 +/- 36.3; P = .01) was significantly higher, whereas the mean HDL-C level (48.8 +/- 11.9 vs 60.5 +/- 10.9 mg/dL; P = .003) was significantly lower in cases as compared to controls.

There was no significant difference in T-Chol and LDL-C levels between cases and controls. The LDL/HDL ratio was significantly higher in cases as compared to controls.

Multiple regression analyses indicated that autism was significantly associated with plasma TG (beta = 31.7 +/- 11.9; P = .01), HDL (beta = -11.6 +/- 2.1; P = .0003), and the LDL/HDL ratio (beta = 0.40 +/- 0.18; P = .04).

There was a significant interaction between autism and TG level in relation to plasma HDL level (P = .02).

Fifty-three percent of variation in the plasma HDL was explained by autism, plasma TG, LDL/HDL ratio, and the interaction between autism and plasma TG level.

These results indicate the presence of dyslipidemia in boys with autism and suggest a possibility that dyslipidemia might be a marker of association between lipid metabolism and autism.

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This entry was posted in Autism, Gut, Immune System, Inflammation, Neurology, Physiology and tagged , , , , , , . Bookmark the permalink.

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