Maternal Inflammation – Significant Role in Autism

Elevated maternal C-reactive protein and autism in a national birth cohort.

http://www.ncbi.nlm.nih.gov/pubmed/23337946

1] Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute, New York, NY, USA [2] Department of Epidemiology, Columbia University Mailman School of Public Health, New York, NY, USA.

Abstract

Autism is a complex neuropsychiatric syndrome with a largely unknown etiology. Inflammation during pregnancy may represent a common pathway by which infections and other insults increase risk for the disorder.

Hence, we investigated the association between early gestational C-reactive protein (CRP), an established inflammatory biomarker, prospectively assayed in maternal sera, and childhood autism in a large national birth cohort with an extensive serum biobank.

Other strengths of the cohort included nearly complete ascertainment of pregnancies in Finland (N=1.2 million) over the study period and national psychiatric registries consisting of virtually all treated autism cases in the population.

Increasing maternal CRP levels, classified as a continuous variable, were significantly associated with autism in offspring. For maternal CRP levels in the highest quintile, compared with the lowest quintile, there was a significant, 43% elevated risk.

This finding suggests that maternal inflammation may have a significant role in autism, with possible implications for identifying preventive strategies and pathogenic mechanisms in autism and other neurodevelopmental disorders.

Molecular Psychiatry advance online publication, 22 January 2013; doi:10.1038/mp.2012.197.

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Further Readings of Interest

https://asdresearchinitiative.wordpress.com/?s=C-reactive

 

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This entry was posted in Autism, co-morbid, Environment, Epigenetics, Immune System, Inflammation, Neurology, Physiology, Treatment and tagged , , , , , , , , , , , , . Bookmark the permalink.

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