Daily Archives: December 15, 2012

Blood Signatures, Neurotrophins, the immune system and Autism.

Characteristics and Predictive Value of Blood Transcriptome Signature in Males with Autism Spectrum Disorders http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3515554/#pone.0049475.s010   Autism Spectrum Disorders (ASD) is a spectrum of highly heritable neurodevelopmental disorders in which known mutations contribute to disease risk in 20% of cases. … Continue reading

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Valproic Acid , GABA , Autism and a Rat

Impairment of cortical GABAergic synaptic transmission in an environmental rat model of autism. http://www.ncbi.nlm.nih.gov/pubmed/23228615 School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, USA. Abstract The biological mechanisms of autism spectrum disorders (ASDs) are largely unknown in … Continue reading

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CDKL5 – MECP2 and a Mouse

Loss of CDKL5 disrupts kinome profile and event-related potentials leading to autistic-like phenotypes in mice. http://www.ncbi.nlm.nih.gov/pubmed/23236174 Departments of Genetics, Neurology, Psychiatry, and Pharmacology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104. Abstract Mutations in the X-linked … Continue reading

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