Daily Archives: August 23, 2012

Human Evolution and the Gene – Implications for Autism

More sophisticated wiring, not just a bigger brain, helped humans evolve beyond chimps http://www.uclahealth.org/body.cfm?id=561&action=detail&ref=1987 Human and chimp brains look anatomically similar because both evolved from the same ancestor millions of years ago. But where does the chimp brain end and … Continue reading

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Stress can effect Multiple Generations

Male Mice Exposed to Chronic Social Stress Have Anxious Female Offspring http://now.tufts.edu/news-releases/male-mice-exposed-chronic-social-stress-have- Tufts University Press Release BOSTON — A study in mice conducted by researchers at Tufts University School of Medicine suggests that a woman’s risk of anxiety and dysfunctional … Continue reading

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Autism in Sweden – Data from Stockholm Youth Cohort

Autism spectrum disorders in the stockholm youth cohort: design, prevalence and validity. http://www.ncbi.nlm.nih.gov/pubmed/22911770 Idring S, Rai D, Dal H, Dalman C, Sturm H, Zander E, Lee BK, Serlachius E, Magnusson C. Source Division of Public Health Epidemiology, Department of Public … Continue reading

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Maternal antibodies and Autism – Review

Maternal and fetal anti-brain antibodies in development and disease. http://www.ncbi.nlm.nih.gov/pubmed/22911883 Recent evidence has emerged indicating that the maternal immune response can have a substantial deleterious impact on prenatal development (Croen et al., 2008). The maternal immune response is largely sequestered … Continue reading

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Microbiology: Inflamed guts boost bad bacteria

Intestinal Inflammation Targets Cancer-Inducing Activity of the Microbiota. http://www.ncbi.nlm.nih.gov/pubmed/22903521 Abstract Inflammation alters host physiology to promote cancer, as seen in colitis-associated colorectal cancer (CRC). Here, we identify the intestinal microbiota as a target of inflammation that impacts the progression of … Continue reading

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Antibiotics and the Gut Microbiome

Antibiotics in early life alter the murine colonic microbiome and adiposity http://www.nature.com/nature/journal/vaop/ncurrent/full/nature11400.html?WT.ec_id=NATURE-20120823 Antibiotics administered in low doses have been widely used as growth promoters in the agricultural industry since the 1950s, yet the mechanisms for this effect are unclear. Because … Continue reading

Posted in Allergy, Asthma, Autism, co-morbid, Environment, Epigenetics, Fragile X, General, Gut, Immune System, Inflammation, Neurology, Physiology, Treatment | Tagged , , , , , , , , , , , , , , , | Leave a comment

Dravet’s Syndrome and Autism SCN1A

Autistic-like behaviour in Scn1a+/− mice and rescue by enhanced GABA-mediated neurotransmission http://www.nature.com/nature/journal/vaop/ncurrent/full/nature11356.html?WT.ec_id=NATURE-20120823 Haploinsufficiency of the SCN1A gene encoding voltage-gated sodium channel NaV1.1 causes Dravet’s syndrome, a childhood neuropsychiatric disorder including recurrent intractable seizures, cognitive deficit and autism-spectrum behaviours. The neural … Continue reading

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Father’s age and Autism

Rate of de novo mutations and the importance of father’s age to disease risk Mutations generate sequence diversity and provide a substrate for selection. The rate of de novo mutations is therefore of major importance to evolution. Here we conduct … Continue reading

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Inflammation and Schizophrenia

Elevated levels of circulating IL-18BP and perturbed regulation of IL-18 in schizophrenia Abstract (provisional) Background The pleiotropic pro-inflammatory cytokine Interleukin (IL)-18 has been proposed to play a role in schizophrenia, since elevated circulating levels of its protein and altered frequencies … Continue reading

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