Gaia, Sunshine and the immune system.

Month of birth, vitamin D and risk of immune-mediated disease: a case control study

http://www.biomedcentral.com/1741-7015/10/69/abstract

Abstract

Background

A season of birth effect in immune-mediated diseases (ID) such as multiple sclerosis and type 1 diabetes has been consistently reported. We aimed to investigate whether season of birth influences the risk of rheumatoid arthritis, Crohn’s disease, ulcerative colitis and systemic lupus erythematosus in addition to multiple sclerosis, and to explore the correlation between the risk of ID and predicted ultraviolet B (UVB) light exposure and vitamin D status during gestation.

Methods

The monthly distribution of births of patients with ID from the UK (n = 115,172) was compared to that of the general population using the Cosinor test. Predicted UVB radiation and vitamin D status in different time windows during pregnancy were calculated for each month of birth and correlated with risk of ID using the Spearman’s correlation coefficient.

Results

The distributions of ID births significantly differed from that of the general population (P = 5e-12) with a peak in April (odds ratio = 1.045, 95% confidence interval = 1.024, 1.067, P < 0.0001) and a trough in October (odds ratio = 0.945, 95% confidence interval = 0.925, 0.966, P < 0.0001). Stratification by disease subtype showed seasonality in all ID but Crohn’s disease. The risk of ID was inversely correlated with predicted second trimester UVB exposure (Spearman’s rho = -0.49, P = 0.00005) and third trimester vitamin D status (Spearman’s rho = -0.44, P = 0.0003).

Conclusions

The risk of different ID in the UK is significantly influenced by the season of birth, suggesting the presence of a shared seasonal risk factor or factors predisposing to ID. Gestational UVB and vitamin D exposure may be implicated in the aetiology of ID.

——————————–

Additional Reading

Full text here – http://www.biomedcentral.com/1741-7015/10/69

BMC Blog here – http://blogs.openaccesscentral.com/blogs/bmcblog/entry/links_between_seasons_sunshine_and

Vitamin D research

Vitamin D, effects on brain development, adult brain function and the links between low levels of vitamin D and neuropsychiatric disease.

http://www.ncbi.nlm.nih.gov/pubmed/22796576

Vitamin D and autism: clinical review.

http://www.ncbi.nlm.nih.gov/pubmed/22522213

Epidemiologic evidence supporting the role of maternal vitamin D deficiency as a risk factor for the development of infantile autism.

http://www.ncbi.nlm.nih.gov/pubmed/20592795

This entry was posted in Autism, co-morbid, Depression, Environment, Physiology and tagged , , , , . Bookmark the permalink.

1 Response to Gaia, Sunshine and the immune system.

  1. Pingback: Autism and Seasons II | asdresearchinitiative

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s