Brain Development and Environment – ASD implications ?

Social deprivation has a measurable effect on brain growth

MRI shows decreased grey and white matter among children in institutional care—but white matter can “catch up” if circumstances improve

July 23, 2012 – Boston Children’s Hospital Press Release.

Boston, Mass.—Severe psychological and physical neglect produces measurable changes in children’s brains, finds a study led by Boston Children’s Hospital. But the study also suggests that positive interventions can partially reverse these changes.

Researchers led by Margaret Sheridan, PhD, and Charles Nelson, PhD, of the Labs of Cognitive Neuroscience at Boston Children’s Hospital, analyzed brain MRI scans from Romanian children in the ongoing Bucharest Early Intervention Project (BEIP), which has transferred some children reared in orphanages into quality foster care homes.

Their findings, published in the Proceedings of the National Academy of Sciences (Early Edition, online the week of July 23), add to earlier studies by Nelson and colleagues showing cognitive impairment in institutionalized children, but also showing improvementswhen children are placed in good foster homes.

“Increasingly we are finding evidence that exposure to childhood adversity has a negative effect on brain development,” says Sheridan. “The implications are wide ranging, not just for institutionalized children but also for children exposed to abuse, abandonment, violence during war, extreme poverty and other adversities.”

Sheridan, Nelson and colleagues compared three groups of 8- to 11-year old children: 29 who had been reared in an institution, 25 who were selected at random to leave the institution for a high-quality foster care placement and 20 typically developing children who were never in an institution.  The children in the middle group had been in foster care for 6 to 9 years.

  • On MRI, children with histories of any institutional rearing had significantly smaller gray matter volumes in the cortex of the brain than never-institutionalized children, even if they had been placed in foster care.
  • Children who remained in institutional care had significantly reduced white matter volume as compared with those never institutionalized.
  • For children who had been placed in foster care, white matter volume was indistinguishable from that of children who were never institutionalized.

The researchers note that growth of the brain’s gray matter peaks during specific times in childhood, indicating sensitive periods when the environment can strongly influence brain development. White matter, which is necessary for forming connections in the brain, grows more slowly over time, possibly making it more malleable to foster care intervention.

“We found that white matter, which forms the “information superhighway” of the brain, shows some evidence of ‘catch up,’” says Sheridan. “These differences in brain structure appear to account for previously observed, but unexplained, differences in brain function.”

“Our cognitive studies suggest that there may be a sensitive period spanning the first two years of life within which the onset of foster care exerts a maximal effect on cognitive development,”Nelson notes. “The younger a child is when placed in foster care, the better the outcome.”

At least 8 million children worldwide live in institutional settings, according to UNICEF, exposing them to severe psychological and physical neglect. In most institutional settings, the ratio of caregivers to children is low (1:12 in these Romanian institutions) and the care highly regimented. Previous studies by Nelson and others have documented deficits in cognitive function, language and social functioning; an increase in stereotypies; markedly elevated rates of attention-deficit/hyperactivity disorder; difficulties with social functioning; and even premature cellular aging.

The Romanian institutions are a legacy of the 1960s, when Romania’s Communist dictator Nicolae Ceausescu taxed all families that had fewer than five children. When families began having children they could not afford, Ceausescu built child placement centers. By 1989, when Ceausescu’s government fell, more than 170,000 Romanian children were living in state-run institutions.

By the time BEIP was begun in 2000, the Romanian government had begun reuniting children with their birth families, cutting Romania’s institutionalized population in half. Spurred by BEIP findings, the government has banned institutionalization for children younger than 2, unless they are profoundly handicapped; they have also started a network of foster care families. (Read more about BEIP here.)

Nathan Fox, PhD, of the University of Maryland, Charles Zeanah, MD, of Tulane University, and Katie McLaughlin, PhD, of Harvard Medical School, Harvard University and Boston Children’s Hospital were co-authors on the paper. The study was funded by the Robert Wood Johnson Health and Society Scholars Program of the Harvard School of Public Health, the John D. and Catherine T. MacArthur Foundation, the Binder Family Foundation, the Help the Children of Romania, Inc. Foundation and National Institute of Mental Health.

Boston Children’s Hospital is home to the world’s largest research enterprise based at a pediatric medical center, where its discoveries have benefited both children and adults since 1869. More than 1,100 scientists, including nine members of the National Academy of Sciences, 11 members of the Institute of Medicine and nine members of the Howard Hughes Medical Institute comprise Boston Children’s research community. Founded as a 20-bed hospital for children, Boston Children’s today is a 395 bed comprehensive center for pediatric and adolescent health care grounded in the values of excellence in patient care and sensitivity to the complex needs and diversity of children and families. Boston Children’s also is the primary pediatric teaching affiliate of Harvard Medical School. For more information about research and clinical innovation at Boston Children’s, visit:


Does poverty and other societal factors influence ‘autism’ diagnosis ? Provocative question or some biological / ecology (developmental programming) that needs to be unpicked ? November 2011 research presented below …

Autism in Glasgow: cumulative incidence and the effects of referral age, deprivation and geographical location.

Referrals to the Greater Glasgow Community Autism Team (CAT) made before the child’s sixth birthday were analysed to obtain an estimation of the proportion of children in Greater Glasgow with childhood autism and investigate whether there were any variations in diagnosis rates, or in age at referral and diagnosis, depending on deprivation or geographical location.

Methods  An analysis was made of the database recording referrals to Greater Glasgow CAT, between 2004 and 2007 inclusive, of children referred by age 6 years, comprising 584 cases. Cumulative incidence was calculated for childhood autism. Ages at referral and diagnosis were also analysed.

Results  For this subset of children, there were 246 diagnosed cases of childhood autism, a cumulative incidence from 2004 until 2007 of 11.1 per year per 10 000 children aged 0-6 years. Of children with an eventual diagnosis of autism by age 6, 72% were referred by the age of 4 years. Deprivation was found to have an association with referral and diagnostic rates, with higher rates seen in the most deprived. There was geographical variation in the cumulative incidence of autism.

Conclusion  Given that the populations were not known to differ in any manner that would lead to a true variation, the geographical variation in the cumulative incidence of autism in children up to 6 years in Greater Glasgow observed in this study is likely to represent differences in the care pathway between areas. Such differences may also explain the observed association with deprivation. Reasons for the variation are being explored.

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