Sleep-potentiated epileptic discharges, language regression, and pediatric thalamic lesions
“Ever since Gloor et al.(1) demonstrated that thalamo-cortical interactions were responsible for generalized seizures, alterations of thalamic function have been investigated in the pathophysiology of epilepsy. Today, the thalamus (in its regulatory, synchronizing actions with the cortex) has been assigned diverse roles. To name just two: 1) in potentiating seizure occurrence during sleep(2); and 2) in its electrical stimulation, treatment of seizures.(3) In addition, recent neuroimaging work has demonstrated heretofore poorly documented anatomic thalamic pathology in generalized epilepsy,(4) and perhaps not coincidentally, in autism.(5).”
The recent Harvard Review of co-morbid conditions found approx 19.4% although this is generally considered to be higher in focused research.
Epilepsy in Young Adults with Autism: A Prospective Population-based Follow-up Study of 120 Individuals Diagnosed in Childhood
Results: Adults with autism and mental retardation constituted a severely disabled group. On a group basis, both the cognitive level and the adaptive behavior level were lower in the epilepsy group than in the nonepilepsy group (p < 0.05). In all, 38% had epilepsy. One third had epilepsy onset before age 2 years. Remission of epilepsy was seen in 16%. Partial seizures with or without secondarily generalized seizures were the dominating seizure type.