PCBs – (polychlorinated biphenyls) and Autism

“ScienceDaily (Apr. 25, 2012) — New research from UC Davis and Washington State University shows that PCBs, or polychlorinated biphenyls, launch a cellular chain of events that leads to an overabundance of dendrites — the filament-like projections that conduct electrochemical signals between neurons — and disrupts normal patterns of neuronal connections in the brain.”

“Impaired neuronal connectivity is a common feature of a number of conditions, including autism spectrum disorders.”

* http://en.wikipedia.org/wiki/Polychlorinated_biphenyl

http://www.sciencedaily.com/releases/2012/04/120425115457.htm

http://psychcentral.com/news/2012/04/26/pcb-exposure-may-increase-risk-of-autism/37872.html

Further readings

Prenatal exposures to persistent and non-persistent organic compounds and effects on immune system development.

http://www.ncbi.nlm.nih.gov/pubmed/18226068

“this report underscores the tight connection between development of the immune system and that of the central nervous system, and the plausibility that disruption of critical events in immune development may play a role in neurobehavioural disorders.”

Perinatal exposure to polychlorinated biphenyls alters social behaviors in rats.

http://www.ncbi.nlm.nih.gov/pubmed/20813172

Perinatal exposure to polychlorinated biphenyls differentially affects cerebellar development and motor functions in male and female rat neonates.

http://www.ncbi.nlm.nih.gov/pubmed/16035193

Effects of polychlorinated biphenyls on the nervous system.

http://www.ncbi.nlm.nih.gov/pubmed/11693948

Disrupting effects of hydroxy-polychlorinated biphenyl (PCB) congeners on neuronal development of cerebellar Purkinje cells: a possible causal factor for developmental brain disorders?

http://www.ncbi.nlm.nih.gov/pubmed/17223178

Image: Victor Habbick / FreeDigitalPhotos.net

 

This entry was posted in Allergy, Asthma, Autism, Environment, Epigenetics, General, Neurology. Bookmark the permalink.

1 Response to PCBs – (polychlorinated biphenyls) and Autism

  1. passionlessdrone says:

    Hi asdresearchinitiative –

    Pessah kicks ass! I got on a rant on another website about the problems with the meme that ‘lead used to be in paint, but now isn’t, so we are exposed to fewer toxins’ nonsense a while ago. While poking around as part of that discussion I ran into some papers by Pessah that are likely part of the underpinnings of this study.

    Para- and ortho-substitutions are key determinants of polybrominated diphenyl ether activity toward ryanodine receptors and neurotoxicity [full free available online] —

    Minding the calcium store: Ryanodine receptor activation as a convergent mechanism of PCB toxicity [full free available online]

    I also saw Pessah speak about a year ago on very similar subjects. The bottom line is that while we were smart enough to alleviate acute problems by banning some types of PCBs, it appears as if we simply replaced them with chemicals with more subtle, but real, effects in physiology. Nice.

    Thanks for bringing this to my attention. How did it get past my pubmed alerts?

    – pD

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